Cold-induced stress stimulates the sympathetic nervous system, causing hypertension and proteinuria in rats
Cold-induced stress stimulates the sympathetic nervous system, causing hypertension and proteinuria in rats
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DOI：
10.1097/00004872-199715040-00009
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发表时间：
1997-04-01
影响因子：
4.9
通讯作者：
Terao, T
中科院分区：
文献类型：
--
作者：
Kanayama, N;Tsujimura, R;Terao, T
目的确定冷应激刺激脚底的爪子在老鼠产生preeclampsia-like综合症,方法:怀孕或产仔的大鼠在0摄氏度,23度室温笼子(cold-stressed组)或在23摄氏度楼和23摄氏度室温笼子(对照组)为2周,他们的血压、蛋白尿,测量血浆儿茶酚胺、组织学研究被执行在所有组。结果实验第1周两组患者收缩压差异无统计学意义；然而，在妊娠的最后一周，冷应激组的血压没有下降，而且明显高于对照组。与对照组相比，冷刺激怀孕大鼠的尿蛋白排泄明显增加。妊娠冷应激大鼠的去甲肾上腺素和肾上腺素浓度明显高于对照大鼠；妊娠冷应激大鼠的滋养细胞侵袭、充血和迷宫纤维蛋白沉积减少；只有妊娠冷应激大鼠的肾小球毛细血管内皮下纤维蛋白沉积明显增加；未怀孕大鼠的组织学发现与怀孕大鼠的几乎相同。结论长期局部冷刺激爪底可引起妊娠大鼠和非妊娠大鼠子痫前期样现象，提示慢性刺激交感神经参与子痫前期的发生。
Objective To determine whether cold-stress stimulation of the soles of the paws would produce a preeclampsia-like syndrome in rats,Methods:Pregnant or nonpregnant rats were kept in 0 degrees C floor and 23 degrees C room temperature cages (the cold-stressed group) or in 23 degrees C floor and 23 degrees C room temperature cages (the control group) for 2 weeks, Their blood pressure, proteinuria, and plasma catecholamines were measured, and histologic studies were performed on all groups.Results There were no significant differences in systolic blood pressure between the two groups during the first week of the experimental period; however, during the last week of gestation the blood pressure of the cold-stressed group did not fall and was significantly higher than that of the control group, A significant increase in urinary protein excretion was observed in the cold-stimulated pregnant rats, in contrast to the control rats. The concentrations of norepinephrine and epinephrine in the cold-stressed pregnant rats were markedly higher than those in the control rats, A decrease in trophoblast invasion, congestion, and fibrinoid deposits of the labyrinth were observed in the cold-stressed rats, A marked increase in subendothelial fibrinoid deposits in the glomerular capillary was found only in the cold-stressed pregnant rats, The blood pressure, biochemical parameters, and histologic findings in the nonpregnant rats were almost the same as those in the pregnant rats.Conclusion Chronic local cold stimulation of the soles of the paws induces preeclampsia-like phenomena in pregnant and nonpregnant rats, and this model suggests that the cause of preeclampsia is involved in chronic stimulation of the sympathetic nerve.