ANTIBODY-RESPONSE TO IMMUNIZATION WITH INFLUENZA A-USSR-77 (H1N1) VIRUS IN YOUNG INDIVIDUALS PRIMED OR UNPRIMED FOR A-NEW-JERSEY-76 (H1N1) VIRUS
ANTIBODY-RESPONSE TO IMMUNIZATION WITH INFLUENZA A-USSR-77 (H1N1) VIRUS IN YOUNG INDIVIDUALS PRIMED OR UNPRIMED FOR A-NEW-JERSEY-76 (H1N1) VIRUS
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DOI：
10.1017/s0022172400069412
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发表时间：
1981-01-01
影响因子：
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通讯作者：
DEJONG, P
中科院分区：
文献类型：
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作者：
MASUREL, N;OPHOF, P;DEJONG, P
鹿特丹港口与运输培训学院(A组)的269名13-20岁的学生和Noordwijk的Willem van den Bergh博士基金会的109名患者(B组)，年龄11-21岁，接种了含有A/USSR/92/77(H1N1)流感病毒血凝素10、20或40微克HA的全病毒疫苗。6wk后，接种20微克/HA的相同病毒的加强疫苗。许多参与者在前两年接种了含有A/新泽西/8/76(H1N1)(A/NJ/76)病毒的全病毒疫苗。副作用大多是温和的，随着疫苗中病毒剂量的增加而增加。在A组中，从未接种过A/NJ/76疫苗的接种者副反应发生率最低。单剂A/USSR/77疫苗不能产生令人满意的同源抗体水平。在用A/USSR/77病毒的20微克HA加强免疫后，如果参与者在前几年没有接种A/NJ/76病毒，他们在所有疫苗剂量组中都显示出更高的同源抗体应答。A/USSR/77病毒初次免疫后，特别是加强免疫后，A/NJ/76病毒免疫的受试者对A/NJ/76病毒有很高的应答率，A/NJ/76抗体水平适中。那些以前没有接种过这种病毒的人对A/NJ/76病毒没有抗体反应或抗体反应很低。
A group of 269 pupils of the Harbor and Transport Training Institute in Rotterdam (group A), aged 13-20 yr and of 109 patients of the Dr Mr Willem van den Bergh Foundation at Noordwijk (group B), aged 11-21 yr, were immunized with a whole virus vaccine containing 10, 20 or 40 .mu.g HA [hemagglutinin] of A/USSR/92/77 (H1N1) influenza virus. A booster vaccination was administered 6 wk later with 20 .mu.g/HA of the same virus. Many of the participants were immunized during the 2 preceding years with a whole virus vaccine containing A/New Jersey/8/76 (H1N1) (A/NJ/76) virus. The side-effects, mostly of a moderate nature, increased with the dose of virus in the vaccine. In group A side effects were least frequent in the vaccinees who had never received A/NJ/76 vaccine. A single dose of A/USSR/77 vaccine did not produce satisfactory levels of homologous antibodies. After booster immunization with 20 .mu.g HA of A/USSR/77 virus participants showed a higher homologous antibody response in all vaccine-dose groups if they were not immunized with A/NJ/76 virus in previous years. After primary and especially after booster immunization with A/USSR/77 virus, a very high response against A/NJ/76 virus and adequate levels of A/NJ/76 antibody were found in participants who were immunized previously with A/NJ/76 virus. Those who had not been immunized with this virus previously showed no or a very low antibody response to A/NJ/76 virus.