Increase Activity of Superoxide Dismutase in Adults Sprague- Dawley Rats Liver After Exposed To Bisphenol A
Increase Activity of Superoxide Dismutase in Adults Sprague- Dawley Rats Liver After Exposed To Bisphenol A
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DOI：
10.9790/2402-08538388
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发表时间：
2014
期刊：
影响因子：
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通讯作者：
Ansoumane Kourouma;D. Peng;Quan Chao;Yaima M. López Tamayo;Liu Changjiang;Wang Chengmin;Fu Wenjuan-
中科院分区：
文献类型：
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作者：
Ansoumane Kourouma;D. Peng;Quan Chao;Yaima M. López Tamayo;Liu Changjiang;Wang Chengmin;Fu Wenjuan-
双酚A(BPA)已被报道可处理肝脏毒性。我们研究了BPA可以通过增加肝脏中的氧化应激来诱导活性氧物种(ROS)的假设。将BPA与玉米油按0、2、10、50 mg/kg体重/d混合均匀制成给药液，每48h给药一次，连续给药20d。最后一次治疗24小时后称重，处死大鼠，取脏器进行分析。治疗组大鼠体重与相应对照组相比无明显变化。双酚A组大鼠肝脏器重量明显减轻。这表明在治疗期间肝脏重量和体重之间不存在线性关系，这表明在相对器官重量方面进行的比较不一定适当地考虑到体重的差异。与对照组相比，BPA处理组大鼠肝组织中抗氧化物酶超氧化物歧化酶(SODS)活性显着升高，提示ROS的过度产生和抗氧化系统的失灵。结果表明，双酚A可通过提高肝脏超氧化物歧化酶活性而诱导大鼠肝脏氧化应激。这些发现为双酚A对肝脏损伤的不良影响提供了可能的毒理学证据。
Bisphenol A (BPA) has been reported to process hepatic toxicity. We investigated the hypothesis that BPA can induce reactive oxygen species (ROS) by increasing oxidative stress in the liver. The dosing solutions were prepared by thoroughly and uniformly mixing BPA in corn oil at 0, 2, 10, 50 mg/kg body weight/day, were administered intraperitoneally every forty-eight hours for 20 days to adults Sprague-Dawley rats. After 24 h of the last treatment, rats were weighed, sacrificed and organs harvested for analysis. The body weight of treated rats did not show significant change as compared with the corresponding control groups. In BPA treated rats there was a significant decrease in the weight of liver organ. Suggesting that there was not a linear relationship between liver weight and body weight during the treatment, suggesting that comparisons made in terms of relative organ weights do not necessarily take proper account of differences in body weight. The activity of antioxidant enzyme superoxide dismutase (SODs) in liver tissue significantly increased in all groups treated with BPA when compared to the control group suggesting uncontrolled overproduction of ROS and failure in antioxidant system. The results indicated that BPA induces oxidative stress in the liver of rats by increasing activity of SOD. These findings provide a possible toxicological evidence of an adverse effect of BPA on liver damage.