MORPHOLOGY OF THE CELLS WITHIN THE INFERIOR TEMPORAL GYRUS THAT PROJECT TO THE PREFRONTAL CORTEX IN THE MACAQUE MONKEY
MORPHOLOGY OF THE CELLS WITHIN THE INFERIOR TEMPORAL GYRUS THAT PROJECT TO THE PREFRONTAL CORTEX IN THE MACAQUE MONKEY
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DOI：
10.1002/cne.902960110
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发表时间：
1990-06-01
影响因子：
2.5
通讯作者：
MORRISON, JH
中科院分区：
文献类型：
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作者：
DELIMA, AD;VOIGT, T;MORRISON, JH
灵长类动物的新大脑皮层具有非凡的区域特化程度。事实上，所有的皮质功能都依赖于相关皮质区域之间相互连接的复杂系统，这些系统允许分布式信息处理。虽然这些皮质皮质的预测组织的某些方面是了解的，很少有人知道灵长类动物的长皮质皮质的预测的起源细胞的形态和传入。我们结合细胞内注射荧光黄（LY）在固定的组织在体内逆行运输的快蓝研究神经元的树突形态的颞下回（ITG）和上级颞沟（STS），提供皮质投射到前额皮质。快蓝逆行标记的细胞在下颞叶皮质内形成两个明确定义的带：一个对应于第III层的颗粒上带和一个对应于第V层和第VI层的颗粒下带。荧光黄细胞内填充后，这些逆行标记的细胞投射到前额叶皮层被发现是形态上非常异质性。虽然所有填充的细胞有刺状树突，他们提出了广泛的细胞体大小和树突树形态。在第III层，大多数细胞是不同大小的典型金字塔。在V-VI层，存在许多典型的锥体细胞。此外，还发现了大量的改良锥体，包括垂直和水平梭形细胞，不对称锥体和多极细胞。在第三层，第五层和第六层的个别亚型的整个树突乔木仅限于几个皮层层，但作为一个群体，这些细胞的树突跨越整个皮层深度。我们认为，皮质投射细胞是不同的subcortically投射细胞，并由一组定义的形态和功能的亚组，其中每一个是由一组不同的传入驱动，并可能具有不同的响应特性。
The primate neocortex possesses an extraordinary degree of regional specialization. Virtually all cortical functions are dependent upon a complex system of reciprocal connections between related cortical regions that allow for distributed information processing. Although some aspects of the organization of these corticocortical projections are understood, little is known about the morphology and afferents to the cells of origin of long corticocortical projections in primates. We combined intracellular injection of Lucifer Yellow (LY) in fixed tissue with in vivo retrograde transport of fast blue to study the dendritic morphology of neurons within the inferior temporal gyrus (ITG) and the superior temporal sulcus (STS) that furnish corticocortical projections to the prefrontal cortex. The fast blue retrogradely labeled cells formed two clearly defined bands within the inferior temporal cortex: a supragranular band that corresponded to layer III, and an infragranular band that corresponded to layers V and VI. After Lucifer Yellow intracellular filling, these retrogradely labeled cells projecting to the prefrontal cortex were found to be morphologically very heterogeneous. Although all filled cells had spiny dendrites, they presented a wide range of cell body sizes and dendritic tree morphologies. In layer III, the majority of cells were typical pyramids of various sizes. In layers V–VI, numerous typical pyramidal cells were present. In addition, significant numbers of modified pyramidal forms were found, including vertical and horizontal fusiform cells, asymmetrical pyramids and multipolar cells. The entire dendritic arbor of individual subtypes in layers III, V, and VI was restricted to a few cortical layers, but as a group these cells had dendrites spanning the whole cortical depth. We suggest that corticocortically projecting cells are distinct from subcortically projecting cells and consist of a defined set of morphological and functional subgroups, each of which is driven by a distinct set of afferents and likely possesses different response properties.