Platelet-neutrophil interactions as drivers of inflammatory and thrombotic disease.

Platelet-neutrophil interactions as drivers of inflammatory and thrombotic disease.
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DOI:
10.1007/s00441-017-2727-4
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发表时间:
2018-03
影响因子:
3.6
通讯作者:
Lisman T
Lisman T
中科院分区:
生物学3区
文献类型:
--
作者:
Lisman T

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中性粒细胞因其在感染和炎症性疾病中的作用而闻名,并且是感染或损伤部位的第一反应者。血小板在止血和血栓形成中具有既定的作用,并且是血管损伤部位的第一反应者。然而,中性粒细胞在血栓形成中的作用越来越被认识到,而血小板的免疫调节特性也越来越被研究。血小板和中性粒细胞在感染、炎症和血栓形成过程中相互作用,并调节彼此的功能。本文将讨论血小板-中性粒细胞相互作用在感染、血栓形成、动脉粥样硬化和组织损伤和修复中的影响。
Neutrophils are well known for their role in infection and inflammatory disease and are first responders at sites of infection or injury. Platelets have an established role in hemostasis and thrombosis and are first responders at sites of vascular damage. However, neutrophils are increasingly recognized for their role in thrombosis, while the immunemodulatory properties of platelets are being increasingly studied. Platelets and neutrophils interact during infection, inflammation and thrombosis and modulate each other’s functions. This review will discuss the consequences of platelet–neutrophil interactions in infection, thrombosis, atherosclerosis and tissue injury and repair.
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