Linkage between Glucose-6-Phosphate Dehydrogenase Deficiency and Manic-Depressive Psychosis
Linkage between Glucose-6-Phosphate Dehydrogenase Deficiency and Manic-Depressive Psychosis
复制标题
6-磷酸葡萄糖脱氢酶缺乏症与躁狂抑郁性精神病之间的联系
DOI：
10.1192/bjp.137.4.337
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发表时间：
1980
影响因子：
10.5
通讯作者：
Jean Wilmotte
中科院分区：
文献类型：
--
作者：
Julien Mendlewicz;Paul Linkowski;Jean Wilmotte
摘要遗传已被证明是躁郁型精神病病因学中的一个重要因素。最近与色盲的连锁研究表明，在躁郁性精神病的传播中存在一个X连锁的显性基因。我们在此报告了在一个信息丰富的家族中，躁郁性精神病和葡萄糖-6-磷酸脱氢酶缺乏症之间存在联系的确凿证据。这些结果加强了先前在情感性疾病中的关联研究，并支持了躁狂-抑郁性精神病亚群中X-连锁的假说。
Summary Heredity has been shown to be an important factor in the aetiology of manic-depressive psychosis. Recent linkage studies with colour blindness have suggested the presence of an X-linked dominant gene in the transmission of manic-depressive psychosis. We report here positive evidence of a linkage between manic-depressive psychosis and glucose-6-phosphate dehydrogenase deficiency in an informative family assorting for both traits. These results strengthen previous linkage studies in affective illness and support the hypothesis of X-linkage in a subgroup of manic-depressive psychosis.