A 3D-MICROPRINTED COAXIAL NOZZLE FOR FABRICATING LONG, FLEXIBLE MICROFLUIDIC TUBING.
A 3D-MICROPRINTED COAXIAL NOZZLE FOR FABRICATING LONG, FLEXIBLE MICROFLUIDIC TUBING.
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用于制造长而灵活的微流体管的 3D 微印刷同轴喷嘴。
DOI：
10.1109/mems58180.2024.10439296
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发表时间：
2024
期刊：
影响因子：
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通讯作者：
Sochol,RyanD
中科院分区：
文献类型：
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作者：
Young,OliviaM;Felix,BaileyM;Fuge,MarkD;Krieger,Axel;Sochol,RyanD
各种新兴应用，特别是医疗和软机器人领域的应用，都取决于制造高度定制化的长而灵活的细观/微流体管的能力。为了满足这一需求，我们在这里提出了一种混合增材制造（或“三维（3D）打印”）策略，该策略涉及三个关键步骤：（i）使用“还原光聚合（VPP）技术，“液晶显示（LCD）”3D打印来打印具有三个入口和三个同心出口的体微流体器件；（ii）使用“双光子直接激光写入（DLW）”直接3D微打印同轴喷嘴(iii) 将石蜡油和液相光固化树脂通过同轴喷嘴挤出到聚二甲基硅氧烷 (PDMS) 通道中进行紫外线曝光，最终生产出所需的管材（由聚合光材料组成），长度任意（例如，> 10 cm），还可以调整不同的输入压力以调整内径 (ID) 和外径。例如，实验结果表明，将液相光材料的驱动压力从 50 kPa 增加到 100 kPa 可使流体管的内径和外径分别为 291±99 μm 和 546±76 μm，达到 741±31 μm 和 888±39 μm。此外，直接 DLW 打印微流体“M”结构的初步结果。管材顶部的图案表明该管材可用于“异位 DLW (esDLW)”制造，这将进一步增强该管材的实用性。
A variety of emerging applications, particularly those in medical and soft robotics fields, are predicated on the ability to fabricate long, flexible meso/microfluidic tubing with high customization. To address this need, here we present a hybrid additive manufacturing (or "three-dimensional (3D) printing") strategy that involves three key steps: (i) using the "Vat Photopolymerization (VPP) technique, "Liquid-Crystal Display (LCD)" 3D printing to print a bulk microfluidic device with three inlets and three concentric outlets; (ii) using "Two-Photon Direct Laser Writing (DLW)" to 3D microprint a coaxial nozzle directly atop the concentric outlets of the bulk microdevice, and then (iii) extruding paraffin oil and a liquid-phase photocurable resin through the coaxial nozzle and into a polydimethylsiloxane (PDMS) channel for UV exposure, ultimately producing the desired tubing. In addition to fabricating the resulting tubing—composed of polymerized photomaterial—at arbitrary lengths (e.g., > 10 cm), the distinct input pressures can be adjusted to tune the inner diameter (ID) and outer diameter (OD) of the fabricated tubing. For example, experimental results revealed that increasing the driving pressure of the liquid-phase photomaterial from 50 kPa to 100 kPa led to fluidic tubing with IDs and ODs of 291±99 μm and 546±76 μm up to 741±31 μm and 888±39 μm, respectively. Furthermore, preliminary results for DLW-printing a microfluidic "M" structure directly atop the tubing suggest that the tubing could be used for "ex situ DLW (esDLW)" fabrication, which would further enhance the utility of the tubing.