Antibacterial neolignans from the leaves of Melaleuca bracteata
Antibacterial neolignans from the leaves of Melaleuca bracteata
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来自白千层叶的抗菌新木脂素
DOI：
10.1016/j.fitote.2017.06.015
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发表时间：
2017-07-01
期刊：
影响因子：
3.4
通讯作者：
Tan, Haibo
中科院分区：
文献类型：
--
作者：
Li, Can;Liu, Hongxin;Tan, Haibo
对白千层叶进行植物化学研究，分离得到10个化合物，其中包括3个新的新木脂素类化合物，命名为白蜡素A-C(1-3)。其中，黑亮蛋白B具有一个罕见的非新木脂素骨架，而黑亮蛋白13和C都含有一个新的醛部分，这可能也是对支链木香香味的反应。它们的结构通过光谱数据解释和仿生全合成得到了广泛的指认。此外，还证实了它们以氧化自由基偶联和Michael加成为关键反应的生物合成途径。抗菌活性评价结果表明，白菜素A对耐甲氧西林的金黄色葡萄球菌具有较强的抗菌活性。
Phytochemical study on the leaves of Melaleuca bracteata resulted in the isolation of ten compounds including three new neolignans, named melaleucins A-C (1-3). Among them, melaleucin B shares a rarely occurring nor-neolignan skeleton, and both melaleucins 13 and C bear a novel aldehyde moiety, which might also be response for the delicate fragrance of M. bracteata. Their structures were extensively assigned by spectral data interpretation and biomimetic total synthesis. Moreover, their biosynthetic pathway with oxidative radical coupling and Michael addition as critical reactions was also confirmed. The antimicrobial activity evaluation revealed that melaleucin A exhibited considerable antimicrobial activity towards methicillin-resistant Staphylococcus aureus.