Effects of melatonin and natural and synthetic analogues of arginine vasotocin on plasma prolactin levels in adult male rats.
Effects of melatonin and natural and synthetic analogues of arginine vasotocin on plasma prolactin levels in adult male rats.
复制标题
褪黑激素和精氨酸催产素的天然和合成类似物对成年雄性大鼠血浆催乳素水平的影响。
作者：
M. K. Vaughan;J. Little;L. Y. Johnson;D. Blask;G. Vaughan;R. Reiter
血浆催乳素显着升高，观察到10分钟后，静脉注射100微克褪黑激素到雌激素-孕酮（EP）启动或非类固醇治疗的雄性大鼠。在EP致敏大鼠中注射后60分钟，用100微克或10 mg褪黑激素处理的组具有显著升高的血浆催乳素水平，而在非类固醇处理的大鼠中用这些相同剂量没有观察到效果。与稀释剂处理的对照组相比，在EP引发的雄性大鼠静脉注射1微克精氨酸催产素（AVT）或1毫克褪黑激素后10，20和60分钟观察到血浆催乳素的显着升高。注射1微克精氨酸加压素、赖氨酸加压素或AVT后，血浆催乳素也明显升高。催产素对血浆催乳素值无影响。静脉注射1 μ g（deamino-1，6 dicarba，8-arginine）-vasotocin可使血浆催乳素在注射后10和20 min显著升高。然而，注射AVT的另一种类似物（4-亮氨酸，8-精氨酸）-催产素，在测量的时间点对催乳素释放没有影响。
A significant elevation in plasma prolactin was observed 10 min following the intravenous injection of 100 microgram of melatonin into either estrogen-progesterone (EP) primed or into nonsteroid-treated male rats. 60 min postinjection in the EP primed rat, the groups treated with 100 microgram or 10 mg of melatonin had signficantly elevated plasma prolactin levels while no effect was observed with these same doses in the nonsteroid-treated rats. Compared to diluent-treated controls, a significant elevation in plasma prolactin was observed at 10, 20 and 60 min following the intravenous injection of either 1 microgram arginine vasotocin (AVT) or 1 mg melatonin into EP primed male rats. A consistent rise in plasma prolactin was also evident after the injection of 1 microgram of either arginine vasopressin, lysine vasopressin or AVT. Oxytocin had no effect on plasma prolactin values. The intravenous administration of 1 microgram of (deamino-1,6 dicarba, 8-arginine)-vasotocin caused a significant elevation of plasma prolactin 10 and 20 min after injection. However, the injection of another analogue of AVT, (4-leucine, 8-arginine)-vasotocin, had no effect on prolactin release at the time points measured.