AMNIOTIC-FLUID INTERLEUKIN-6 DETERMINATIONS ARE OF DIAGNOSTIC AND PROGNOSTIC VALUE IN PRETERM LABOR
AMNIOTIC-FLUID INTERLEUKIN-6 DETERMINATIONS ARE OF DIAGNOSTIC AND PROGNOSTIC VALUE IN PRETERM LABOR
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DOI：
10.1111/j.1600-0897.1993.tb00618.x
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发表时间：
1993-09-01
影响因子：
3.6
通讯作者：
SEHGAL, PB
中科院分区：
文献类型：
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作者：
ROMERO, R;YOON, BH;SEHGAL, PB
问题：本研究的目的是确定如果羊水浓度的白细胞介素-6（IL-6）的诊断价值的微生物入侵的羊膜腔和预测失败的安胎，早产和围产期发病率和mortality.METHOD：羊水获得经腹穿刺术从146个连续的患者入院诊断早产和完整的膜。培养液体中的需氧菌和厌氧菌以及支原体。使用基于单克隆抗体的酶联免疫吸附试验测量羊水IL-6水平，灵敏度为0.03 ng/ml。Logistic回归和考克斯的比例风险模型被用来检查的影响，几个变量对二分的结果或间隔，以deliver.Results：患者与羊水培养阳性有显着较高的羊水IL，6浓度比患者与阴性文化（中位数91.2 ng/ml，范围0.9至437 ng/ml对中位数0.4 ng/ml，范围
PROBLEM: The purpose of this study was to determine if amniotic fluid concentrations of the interleukin-6 (IL-6) are of value in diagnosis of microbial invasion of the amniotic cavity and in the prediction of failure of tocolysis, preterm delivery and perinatal morbidity and mortality.METHOD: Amniotic fluid was obtained by transabdominal amniocentesis from 146 consecutive patients admitted with the diagnosis of preterm labor and intact membranes. Fluid was cultured for aerobic and anaerobic bacteria as well as for mycoplasmas. Amniotic fluid IL-6 levels were measured using a monoclonal antibody-based enzyme-linked immunosorbent assay with a sensitivity of 0.03 ng/ml. Logistic regression and Cox's proportional hazards model were used to examine the effect of several variables on dichotomous outcomes or interval to delivery.RESULTS: Patients with a positive amniotic fluid culture had a significantly higher amniotic fluid IL,6 concentrations than patients with a negative culture (median 91.2 ng/ml, range 0.9 to 437 ng/ml versus median 0.4 ng/ml, range