Mapping the risk of mesothelioma due to neighborhood asbestos exposure
Mapping the risk of mesothelioma due to neighborhood asbestos exposure
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DOI：
10.1164/rccm.200801-063oc
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发表时间：
2008-09-15
影响因子：
24.7
通讯作者：
Kumagai, Shinji
中科院分区：
文献类型：
--
作者：
Kurumatani, Norio;Kumagai, Shinji
基本原理：关于石棉和间皮瘤的危险在附近的居民中的一个工业源的石棉sources.Objectives的邻居暴露知之甚少：调查居民中的石棉暴露水平的危险程度，并确定受石棉影响的区域的范围。我们计算了1995年至2006年间皮瘤的标准化死亡率，估计人群中的风险，生活在一个前大石棉1957年至1975年，日本天崎市的水泥管道厂使用了青石棉和温石棉。工厂和住宅之间的距离和相对石棉浓度扩散方程，涉及气象条件，用于确定石棉暴露水平之间residents. Measures和主要结果：我们确定了73间皮瘤死亡的35名男性和38名女性谁没有职业暴露于石棉。在工厂半径300米范围内居住的人中，间皮瘤的标准化死亡率男性为13.9（95%置信区间，5.6-28.7），女性为41.1（95%置信区间，15.2-90.1）。当研究区域被划分为五个区域的相对石棉浓度，间皮瘤的标准化死亡率下降，男女，在线性剂量依赖性的方式与浓度。标准化死亡率显著升高的地区达到2,200米，从工厂在同一方向，其中风主要blowed.Conclusions：邻居接触石棉可以构成严重的风险，居民在很大的区域。
Rationale: Little is known about neighborhood exposure to asbestos and mesothelioma risk among residents around an industrial source of asbestos.Objectives: To investigate the magnitude of the risk among residents by asbestos exposure levels and to determine the range of the area affected by asbestos.Methods: We calculated standardized mortality ratios of mesothelioma from 1995 to 2006 among the estimated population at risk that lived around a former large asbestos cement pipe plant in Amagasaki City, Japan, between 1957 and 1975, the time when the plant had used crocidolite and chrysotile. The distance between the plant and homes and relative asbestos concentrations obtained by diffusion equations involving meteorological conditions were used to determine asbestos exposure levels among residents.Measurements and Main Results: We identified 73 mesothelioma deaths of 35 men and 38 women who had no occupational exposure to asbestos. Among persons who had lived within a 300-m radius of the plant, the standardized mortality ratio of mesothelioma was 13.9 (95% confidence interval, 5.6-28.7) for men and 41.1 (95% confidence interval, 15.2-90.1) for women. When the study area was divided into five regions by relative asbestos concentration, standardized mortality ratios of mesothelioma declined, for both sexes, in a linear dose-dependent manner with concentration. The regions with a significantly elevated standardized mortality ratio reached 2,200 m from the plant in the same direction in which the wind predominantly blew.Conclusions: Neighborhood exposure to asbestos can pose a serious risk to residents across a wide area.