Selective inhibition of cyclooxygenase 2 spares renal function and prostaglandin synthesis in cirrhotic rats with ascites
Selective inhibition of cyclooxygenase 2 spares renal function and prostaglandin synthesis in cirrhotic rats with ascites
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DOI：
10.1016/s0016-5085(99)70020-x
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发表时间：
1999-05-01
期刊：
影响因子：
29.4
通讯作者：
Rodés, J
中科院分区：
文献类型：
--
作者：
Bosch-Marcé, M;Clària, J;Rodés, J
背景与目的：环氧化酶（COX）产品在肝硬化腹水患者肾功能维持中的关键作用，不鼓励在这种疾病中使用非甾体类抗炎药。选择性COX-2抑制剂的最新发展为这些化合物在失代偿性肝硬化中的应用开辟了新的途径。目前的研究评估了选择性COX-2抑制剂（SC-236）对肝硬化腹水大鼠肾功能的影响。在方案1中，测定肝硬化大鼠在给予SC-236 （n = 12）或酮咯酸（n = 10）前后的尿量、尿钠和前列腺素排泄量、肾小球滤过率和肾血浆流量。方案2旨在评估COX抑制剂对28只肝硬化大鼠肾脏水代谢的影响。肝硬化动物服用SC-236对肾脏没有明显影响，而服用非选择性COX-1/COX-2抑制剂酮咯酸（ketorolac）可显著减少尿量、尿中前列腺素的排泄和肾小球滤过率，并显著损害肾脏水代谢。结论：这些发现表明SC-236对肝硬化大鼠的肾功能没有明显损害。
Background & Aims: The critical role of cyclooxygenase (COX) products in maintenance of renal function in cirrhosis with ascites discourages the use of nonsteroidal anti-inflammatory drugs in this disease. The recent development of selective COX-2 inhibitors opens new avenues for the use of these compounds in decompensated cirrhosis, The current study evaluates the effects of a selective COX-2 inhibitor (SC-236) on renal function in cirrhotic rats with ascites, Methods: In protocol 1, urine volume, urinary excretion of sodium and prostaglandins, glomerular filtration rate, and renal plasma flow were measured before and after administration of SC-236 (n = 12) or ketorolac (n = 10) to rats with cirrhosis, Protocol 2 was aimed at assessing the effects of COX inhibitors on renal water metabolism in 28 cirrhotic rats, Results: Administration of SC-236 to cirrhotic animals did not produce significant renal effects, whereas administration of the nonselective COX-1/COX-2 inhibitor, ketorolac, resulted in a marked reduction in urine volume, urinary excretion of prostaglandins, and glomerular filtration rate and in a significant impairment in renal water metabolism. Conclusions: These findings indicate that SC-236 does not significantly impair renal function in rats with cirrhosis.