Exosomes and Cardiovascular Protection.
Exosomes and Cardiovascular Protection.
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DOI：
10.1007/s10557-016-6698-6
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发表时间：
2017-02
影响因子：
3.4
通讯作者：
Yellon DM
中科院分区：
文献类型：
--
作者：
Davidson SM;Takov K;Yellon DM
大多数（如果不是全部的话）心血管系统的细胞分泌称为外泌体的小的脂质双层囊泡。尽管在其纯化和分析方面存在技术挑战，但来自各种来源的外泌体已被证明具有强大的心脏保护作用。事实上，通过干细胞治疗获得的心血管功能中的许多所谓的“旁分泌”益处可以通过注射干细胞产生的外泌体来复制。然而，从血浆中纯化的外泌体似乎同样能够激活心脏保护途径。我们讨论了内源性外泌体在心血管系统中的潜在作用，这在心血管疾病中是如何被干扰的，并评估了它们作为保护心脏的治疗药物的潜力。
Most, if not all, cells of the cardiovascular system secrete small, lipid bilayer vesicles called exosomes. Despite technical challenges in their purification and analysis, exosomes from various sources have been shown to be powerfully cardioprotective. Indeed, it is possible that much of the so-called “paracrine” benefit in cardiovascular function obtained by stem cell therapy can be replicated by the injection of exosomes produced by stem cells. However, exosomes purified from plasma appear to be just as capable of activating cardioprotective pathways. We discuss the potential roles of endogenous exosomes in the cardiovascular system, how this is perturbed in cardiovascular disease, and evaluate their potential as therapeutic agents to protect the heart.