Seasonal changes of serum 25-hydroxyvitamin D and intact parathyroid hormone levels in a normal Japanese population
Seasonal changes of serum 25-hydroxyvitamin D and intact parathyroid hormone levels in a normal Japanese population
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DOI：
10.1007/s00774-004-0553-8
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发表时间：
2005-03-01
影响因子：
3.3
通讯作者：
Itoh, M
中科院分区：
文献类型：
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作者：
Ono, Y;Suzuki, A;Itoh, M
我们进行了一项观察性研究，以评估日本东海地区(N35.3 E137.0)197名正常受试者维生素D缺乏症的患病率及其季节变化。血清25-羟基维生素D(25-OHD)水平以冬末最低，夏末最高(3月份15.1+/-7.1 ng/ml；6月份21.5+/-5.5 ng/ml；9月份31.6+/-5.6 ng/ml；12月份23.1+/-5.3 ng/ml；平均值+/-SD)。3月、6月、9月和12月维生素D缺乏症患病率分别为86.7%、33.4%、1.0%和26.0%。血浆全段甲状旁腺激素(IPTH)浓度在夏末最低，冬季末最高(3月份28.2+/-9.3pg/ml；6月份21.7+/-7.0pg/ml；9月份19.8+/-6.9pg/ml；12月份25.7+/-9.2pg/ml；平均值+/-SD)。血清25-OHD与iPTH呈负相关(相关系数为-0.223；r=0.251；P<；0.001)。男性血清25-OHD水平高于女性。血清25-OHD水平与年龄、体重、体重指数呈正相关，与体脂含量无关。这些结果表明，在日本，即使在阳光明媚的地区，冬季与iPTH升高相关的维生素D缺乏症的患病率也很高。
We conducted an observational study in order to assess the prevalence of hypovitaminosis D and its seasonal changes, in the Tokai area (N35.3 E137.0), in 197 normal subjects in Japan. The mean serum 25-hydroxyvitamin D (25-OHD) level measured by direct radioimmunoassay (RIA) was lowest at the end of winter, and highest at the end of summer (15.1 +/- 7.1 ng/ml in March; 21.5 +/- 5.5 ng/ml in June; 31.6 +/- 5.6 ng/ml in September; 23.1 +/- 5.3 ng/ml in December; mean +/- SD). The prevalence of hypovitaminosis D ( < 20 ng/ml) was 86.7%, 33.4%, 1.0%, and 26.0% in March, June, September, and December, respectively. Mean plasma intact parathyroid hormone (iPTH) concentration was lowest at the end of summer and highest at the end of winter (28.2 +/- 9.3 pg/ml in March; 21.7 +/- 7.0 pg/ml in June; 19.8 +/- 6.9 pg/ml in September; and 25.7 +/- 9.2 pg/ml in December; mean +/- SD). Serum 25-OHD was inversely associated with iPTH ( coefficient, - 0.223; r = 0.251; P < 0.001). Serum 25-OHD levels were higher in men than in women. The serum 25-OHD level was positively associated with age, body weight, and body mass index, but not with body fat content. These results suggest a high prevalence of hypovitaminosis D associated with elevation of iPTH in Japan, in winter, even in a sunny area.