The role of gap junctions in seizures
The role of gap junctions in seizures
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DOI：
10.1016/s0165-0173(99)00084-3
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发表时间：
2000-04-01
影响因子：
--
通讯作者：
Velazquez, JLP
中科院分区：
文献类型：
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作者：
Carlen, PL;Skinner, F;Velazquez, JLP
神经元之间通过缝隙连接进行电紧张性突触通讯越来越被认为是大脑中一种重要的同步机制。与此同时，中枢神经系统（CNS）gjs的生物学正在解开。癫痫发作背后的异常神经元同步性的发病机制，以前认为主要是基于化学突触传递，现在包括间隙连接通讯的作用。这一概念已被几种体外癫痫发作模型的证据所加强，其中间隙连接通讯的药理学操作可预测地影响癫痫发作的产生：阻断剂减少癫痫发作，增强剂增加癫痫发作。中间神经元的证据，耦合部分由gjs，产生同步神经网络活动，包括癫痫发作，提出。此外，神经建模的研究，这提高了我们的能力，以了解功能的作用，间隙连接通信的产生和维持神经同步性和癫痫发作，提出。缝隙连接通讯似乎是未来抗惊厥治疗发展的一个有前途的目标。(C)2000 Elsevier Science B.V.保留所有权利。
Electrotonic synaptic communication between neurons via gap junctions (gjs) is increasingly recognized as an important synchronizing mechanism in the brain. At the same time, the biology of central nervous system (CNS) gjs is being unravelled. The pathogenesis of the abnormal neuronal synchrony underlying seizures, formerly thought to be based mainly on chemical synaptic transmission, now includes a role for gap junctional communication. This concept has been strengthened by evidence from several in vitro seizure models, in which pharmacological manipulations of gap junctional communication predictably affect the generation of seizures: blockers diminishing seizures and enhancers increasing the seizures. Evidence for interneurons, coupled in part by gjs, generating synchronous neural network activity including seizures, is presented. Also neuromodelling studies, which have enhanced our ability to understand the functional role that gap junctional communication plays in the generation and maintenance of neural synchrony and seizures, are presented. Gap junctional communication appears to be a promising target for the development of future anticonvulsant therapy. (C) 2000 Elsevier Science B.V. All rights reserved.