Immunological evidence that insulin activates protein kinase C in BC3H-1 myocytes.
Immunological evidence that insulin activates protein kinase C in BC3H-1 myocytes.
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免疫学证据表明胰岛素激活 BC3H-1 肌细胞中的蛋白激酶 C。
DOI：
10.1016/0014-5793(89)81186-x
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发表时间：
1989
期刊：
影响因子：
3.5
通讯作者：
Farese,RV
中科院分区：
文献类型：
--
作者：
Acevedo-Duncan,M;Cooper,DR;Standaert,ML;Farese,RV
研究胰岛素对BC3H-1肌细胞免疫反应蛋白激酶C的影响。胰岛素引起胞质酶的剂量依赖性快速下降，膜相关酶的短暂增加和随后的减少。佛波酯引发了类似的变化。我们的研究结果表明，胰岛素可引起蛋白激酶C的易位活化。
Effects of insulin on immunoreactive protein kinase C were examined in BC3H-1 myocytes. Insulin provoked rapid dose-dependent decreases in cytosolic enzyme, and transient increases and subsequent decreases in membrane-associated enzyme. Phorbol esters provoked similar changes. Our findings suggest that insulin provokes the translocative activation of protein kinase C.