Infective endocarditis caused by Enterococcus faecalis treated with continuous infusion of ampicillin without adjunctive aminoglycosides.
Infective endocarditis caused by Enterococcus faecalis treated with continuous infusion of ampicillin without adjunctive aminoglycosides.
复制标题
粪肠球菌引起的感染性心内膜炎，持续输注氨苄西林，不加用氨基糖苷类药物。
DOI：
10.2169/internalmedicine.52.8425
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发表时间：
2013
影响因子：
1.2
通讯作者：
K. Mikasa
中科院分区：
文献类型：
--
作者：
Taku Ogawa;Masatoshi Sato;Shinsuke Yonekawa;Chiyo Nakagawa;K. Uno;K. Kasahara;K. Maeda;M. Konishi;K. Mikasa
氨基糖苷类药物是治疗感染性心内膜炎的有效抗菌剂，但它们有时也会引起麻烦的副作用，如肾毒性和耳毒性。我们在此报告一例由粪肠球菌引起的感染性心内膜炎，经持续输注氨苄西林治疗成功，且无辅助氨基糖苷类药物。氨苄西林血药浓度高于靶菌的最低抑菌浓度。尽管目前避免使用氨苄西林单一疗法，因为据报道双重β-内酰胺疗法更有效，但持续给予青霉素仍然是治疗感染性心内膜炎的有效选择。
Aminoglycosides are useful antimicrobial agents for treating infective endocarditis; however, they occasionally cause troublesome side effects, such as nephrotoxicity and ototoxicity. We herein report a case of infective endocarditis caused by Enterococcus faecalis that was treated successfully with continuous infusion of ampicillin without adjunctive aminoglycosides. The serum ampicillin concentrations were higher than the minimal inhibitory concentration for the target strain. Although the use of ampicillin monotherapy is currently avoided because double β-lactam therapy is reportedly more effective, continuous penicillin administration remains an effective therapeutic choice for treating infective endocarditis.
影响因子：
6.4
作者：
Zhao, XL;Drlica, K
通讯作者：
Drlica, K
影响因子：
11.8
作者：
Zhao, XL;Drlica, K
通讯作者：
Drlica, K