Biochemical markers of bone turnover after surgical menopause and hormone replacement therapy
Biochemical markers of bone turnover after surgical menopause and hormone replacement therapy
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DOI：
10.1016/s8756-3282(99)00175-1
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发表时间：
1999-09-01
期刊：
影响因子：
4.1
通讯作者：
Muñoz-Gómez, J
中科院分区：
文献类型：
--
作者：
Peris, P;Alvarez, L;Muñoz-Gómez, J
本研究的目的是评估手术绝经和激素替代治疗(HRT)对新的骨转换生化标志物的影响。14名绝经后3个月开始接受激素替代治疗的女性被招募进行为期一年的研究。结果与31名年龄相近的健康绝经前妇女的对照组进行了比较。测定血清总碱性磷酸酶、骨碱性磷酸酶、I型前胶原羧基和氨基末端(PICP、PINP)、骨钙素、抗酒石酸酸性磷酸酶、I型胶原羧基末端多肽(ICTP和血清CTX)，尿样分别于手术绝经后3个月、HRT后3个月和9个月检测尿液中羟脯氨酸、吡啶啉、脱氧吡啶啉、I型胶原α和β-羧基末端多肽(α-CTX和β-CTX)、I型胶原氨基末端多肽(ICTP)。绝经后各项生化指标均升高，HRT治疗9个月后大部分指标恢复正常。在骨形成标志物中，术后血清PINP升高的比例最高(62%)，平均增加百分比最高(101%)。在绝经后妇女的骨吸收指标中，尿β-CTX、α-CTX、NTX和血清CTX的增加值比例最高(分别为100%、67%、58%、58%)，且平均增加百分比最大。它们也是对HRT反应最显著的标记物。总之，血清PINP是骨形成最敏感的标记物，而β-CTX是手术绝经后骨吸收最敏感的标记物。此外，两种标记物在激素替代治疗后的反应都最高。(C)1999，爱思唯尔科学公司。保留所有权利。
The objective of this study was to evaluate the effect of surgical menopause and hormone replacement therapy (HRT) on the new biochemical markers of bone turnover. Fourteen women who had undergone surgical menopause and began HRT 3 months after surgery were recruited for a 1-year study. Results were compared with a control group of 31 healthy premenopausal women of similar age. Serum samples were obtained to determine total alkaline phosphatase, bone alkaline phosphatase, propeptides carboxy- and amino-terminal of type I procollagen (PICP, PINP), osteocalcin, tartrate-resistant acid phosphatase, and carboxyterminal telopeptides of type I collagen (ICTP and serum CTX), Urine samples were analyzed for hydroxyproline, pyridinoline, deoxypyridinoline, alpha and beta-carboxy-terminal telopeptides of type I collagen (alpha-CTX and beta-CTX), and amino-terminal telopeptides of type I collagen (ICTP), Determinations were performed after 3 months of surgical menopause and after 3 and 9 months of HRT. All biochemical markers increased after menopause, and most of them normalized after 9 months of HRT. Serum PINP showed the highest proportion of increased values after surgery among bone formation markers (62%), as well as the highest mean percent increase (101%). Among bone resorption markers in postmenopausal women, urinary beta-CTX, alpha-CTX, NTX, and serum CTX showed the highest proportion of increased values (100%, 67%, 58%, 58%, respectively) as well as the greatest mean percent increase. They were also the markers with the most marked response to HRT. In conclusion, serum PINP is the most sensitive marker of bone formation, whereas beta-CTX is the most sensitive marker of bone resorption after surgical menopause. In addition, both markers showed the highest response after HRT. (C) 1999 by Elsevier Science Inc. All rights reserved.