PORPHYROMONAS-GINGIVALIS OUTER-MEMBRANE VESICLES PROMOTE BACTERIAL-RESISTANCE TO CHLORHEXIDINE
PORPHYROMONAS-GINGIVALIS OUTER-MEMBRANE VESICLES PROMOTE BACTERIAL-RESISTANCE TO CHLORHEXIDINE
复制标题
DOI：
10.1111/j.1399-302x.1995.tb00161.x
复制
发表时间：
1995-10-01
影响因子：
--
通讯作者：
MAYRAND, D
中科院分区：
文献类型：
--
作者：
GRENIER, D;BERTRAND, J;MAYRAND, D
牙龈卟啉单胞菌经常与某些类型的牙周疾病相关，并具有多种促进致病过程的机制。最近观察到，牙龈假单胞菌精心制作的囊泡能够保护细菌免受人血清的杀菌活性的影响。本研究的目的是评价牙龈假单胞菌囊泡对洗必泰口腔细菌的保护作用。数据表明，牙龈假单胞菌释放的小泡可能与洗必泰结合，从而保护自身和其他口腔细菌物种。研究还表明，脂多糖是洗必泰与囊泡结合的主要成分。本研究中报道的耐药机制表明，口腔内细菌的相互作用可能会影响微生物的敏感性。
Porphyromonas gingivalis has been frequently associated with some types of periodontal diseases and possesses various mechanisms favoring the pathogenic process. It has been recently observed that vesicles elaborated by P. gingivalis are able to protect bacteria from the bactericidal activity of human serum. The aim of the present investigation was to evaluate the ability of vesicles from P, gingivalis in protecting oral bacteria against chlorhexidine. Data indicate that vesicles released by P, gingivalis may bind chlorhexidine, thus allowing protection for itself and for other oral bacterial species. It has also been demonstrated that lipopolysaccharides are the major component involved in the binding of chlorhexidine by vesicles. The mechanism of resistance reported in this study indicates that bacterial interactions in the oral cavity may influence the sensitivity of microbes.