Neurocognitive functioning in dually diagnosed middle aged and elderly patients with alcoholism and schizophrenia.
Neurocognitive functioning in dually diagnosed middle aged and elderly patients with alcoholism and schizophrenia.
复制标题
双重诊断的中老年酒精中毒和精神分裂症患者的神经认知功能。
DOI：
10.1002/gps.1528
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发表时间：
2006
影响因子：
4
通讯作者：
Jeste,DV
中科院分区：
文献类型：
--
作者：
Mohamed,S;Bondi,MW;Kasckow,JW;Golshan,S;Jeste,DV
背景酒精滥用和依赖对精神分裂症患者的管理具有重要的临床意义。精神分裂症患者的酒精中毒可影响其病程和预后，本研究旨在比较中老年精神分裂症患者与酒精滥用/依赖者与非酒精滥用/依赖者的认知状况、症状特征和生活质量。我们最初假设，在这个年龄组中，更多的精神分裂症男性会表现出酗酒。我们还研究了45-54岁年龄组的特点与那些≥ 55岁的组，并假设合并症与酒精将与更坏的认知和生活质量在以后的life.MethodsData从数据库中获得的服务和干预研究中心在加州，圣地亚哥大学。患者被诊断为精神分裂症或情感性精神障碍。收集的数据包括人口统计学特征、认知状态（使用Mattis痴呆评定量表学习、韦氏记忆量表修订版的图形和故事记忆测试以及加州言语学习测试[CVLT]进行测试）。此外，患者进行了精神病理学评估和筛选的生活质量使用的质量幸福scale.ResultsWe表明，老年患者酗酒有更差的分数评估认知相对于相同年龄组无酗酒。此外，他们的认知得分相对于年轻的酗酒组（45-54岁）更差。在生活质量方面没有显著差异。此外，更多的男性比女性表现出alcoholisation.ConclusionThe结果是一致的前提下，较高的认知功能，在年轻的精神分裂症患者酗酒似乎掩盖了酒精使用对认知的影响，在这个年龄。然而，对于老年精神分裂症患者，酒精使用对神经心理功能的影响似乎是有害的。版权所有© 2006约翰威利父子有限公司。
BackgroundAlcohol abuse and dependence have important clinical implications for managing patients with schizophrenia. Alcoholism in schizophrenia patients can interfere with the course and prognosis of the schizophrenic illness.ObjectiveThe purpose of the present study was to compare the cognitive status, symptom profile and quality of life of middle aged and older patients (>44 years old) with schizophrenia and alcohol abuse/dependencevsthose without alcohol abuse/dependence. We initially hypothesized that more males in this age group with schizophrenia would exhibit alcoholism. We also examined the characteristics of the 45–54 year age group with those of the ≥ 55 year old group and hypothesized that comorbidity with alcohol would be associated with worse cognition and quality of life in later life.MethodsData were obtained from a database from the Center for Services and Interventions research at the University of California, San Diego. Patients had diagnoses of schizophrenia or schizoaffective disorder. Data collected included demographic characteristics, cognitive status (tested with the Mattis Dementia Rating Scale learning, the Figural and Story Memory Test of the Wechsler Memory Scale‐Revised and the California Verbal Learning Test [CVLT]). In addition, patients had undergone psychopathologic assessment and were screened for quality of life using the Quality of Well Being scale.ResultsWe demonstrated that the older aged patients with alcoholism had worse scores assessing cognition relative to the same aged group without alcoholism. In addition, they had worse cognitive scores relative to the younger group (45–54 year old) with alcoholism. There was no significant difference with regards to quality of life. In addition, more males than females exhibited alcoholism.ConclusionThe results are consistent with the premise that the higher cognitive function in the younger schizophrenia patients with alcoholism appear to mask the effects of alcohol use on cognition at that age. However, for the older group of schizophrenia patients, the effects of alcohol use on neuropsychological functioning appear to be deleterious. Copyright © 2006 John Wiley & Sons, Ltd.