Phototoxic reactions to photoactive drugs in patients treated with PUVA.
Phototoxic reactions to photoactive drugs in patients treated with PUVA.
复制标题
使用 PUVA 治疗的患者对光活性药物的光毒性反应。
DOI：
10.1001/archderm.1980.01640350059015
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发表时间：
1980
影响因子：
--
通讯作者：
H. L. Bleich
中科院分区：
文献类型：
--
作者：
R. Stern;R. Kleinerman;J. Parrish;T. Fitzpatrick;H. L. Bleich
为了确定光活性药物联合口服甲氧沙林光化学疗法(PUVA)治疗银屑病的潜在不良反应，我们在15个中心研究了接受PUVA治疗的1125名患者的光毒性反应发生率。在PUVA治疗的初始(清除)阶段，使用光活性药物的患者并不比没有使用此类药物的患者更有可能出现弥漫性延迟性红斑。在清除后，使用光活性药物的45岁或45岁以上的患者由于与紫外线引起的烧伤有关的问题而中断PUVA治疗至少一个月的可能性是不使用此类药物的患者的2.3倍。在服用光活性药物的45岁以上的患者中，只有6%的人存在严重的光毒性问题，导致永久停止PUVA治疗。
To determine the potentially adverse effects of photoactive medications taken in conjunction with oral methoxsalen photochemotherapy (PUVA) for psoriasis, we studied the incidence of phototoxic reactions in 1,125 patients treated with PUVA at 15 centers. During the initial (clearing) phase of PUVA therapy, patients using photoactive medications were no more likely to have diffuse delayed erythema than patients who did not use such medications. After clearing, patients 45 years of age or older who used photoactive drugs were 2.3 times as likely to discontinue PUVA therapy for at least one month owing to problems related to UV-induced burns than were those who did not use such drugs. Only 6% of patients older than 45 years who took photoactive medications had problems with phototoxicity sufficiently severe to contribute to permanent discontinuation of PUVA therapy.