Nitric oxide in adult lung disease
Nitric oxide in adult lung disease
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DOI：
10.1378/chest.115.5.1407
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发表时间：
1999-05-01
期刊：
影响因子：
9.6
通讯作者：
Hart, CM
中科院分区：
文献类型：
--
作者：
Hart, CM
在了解一氧化氮作为一种生物介质和治疗工具的进展继续以快速的速度积累。这篇综述提供了有关一氧化氮在成人肺部疾病中的作用的最新进展。在简要回顾了基本的一氧化氮生物化学和生理学之后，本文考虑了支持一氧化氮在正常肺血管和气道张力调节中的作用的证据。本文综述了一氧化氮在肺动脉高压、气道疾病和肺损伤中的病理生理作用的临床研究，并讨论了吸入性一氧化氮治疗的应用。
Advances in the understanding of nitric oxide as a biological mediator and a therapeutic tool continue to accumulate at a rapid rate. This review provides an update on recent developments pertinent to the role of nitric oxide in adult lung disease. After a brief review of basic nitric oxide biochemistry and physiology, the evidence supporting the role of nitric oxide in the regulation of vascular and airway tone in the normal lung is considered. Clinical studies addressing the pathophysiological role of nitric oxide in pulmonary hypertension, airway disease, and lung injury are reviewed, and the application of inhaled nitric oxide therapy is discussed.