Lung cancer risk among German male uranium miners: a cohort study, 1946-1998
Lung cancer risk among German male uranium miners: a cohort study, 1946-1998
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DOI：
10.1038/sj.bjc.6603403
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发表时间：
2006-11-06
影响因子：
8.8
通讯作者：
Tschense, A.
中科院分区：
文献类型：
--
作者：
Grosche, B.;Kreuzer, M.;Tschense, A.
从1946年至1990年，在前德意志民主共和国南部进行了大规模的铀矿开采。整个劳动力包括10万人。建立了Wismut公司59001名前男性雇员的队列，形成了1946-1998年期间大型回顾性铀矿工人队列。平均随访时间为30.5年，随访总人数为1 801 630人年。随访损失较低，为5.3%。在研究期间，有16598人（28.1%）死亡。基于2388例肺癌死亡病例，对氡相关肺癌风险进行了评估。每个工作水平月（WLM）的超额相对风险（ERR）估计为0.21% （95% CI: 0.18-0.24）。它取决于暴露后的时间和达到的年龄。最高的ERR/WLM出现在接触后15-24岁和最年轻的年龄组（< 55岁）。虽然在高暴露中发现了很强的反向暴露率效应，但在低于100 WLM的暴露中没有发现显著的关联。过量相对风险/WLM不受暴露时间的影响。结果表明需要重新评估当前风险模型中风险修正因素的影响，因为暴露时间并没有改变ERR/WLM，并且随着暴露时间的增加，ERR/WLM只有适度的下降。
From 1946 to 1990 extensive uranium mining was conducted in the southern parts of the former German Democratic Republic. The overall workforce included several 100 000 individuals. A cohort of 59 001 former male employees of the Wismut Company was established, forming a large retrospective uranium miners' cohort for the time period 1946-1998. Mean duration of follow-up was 30.5 years with a total of 1 801 630 person-years. Loss to follow-up was low at 5.3%. Of the workers, 16 598 (28.1%) died during the study period. Based on 2388 lung cancer deaths, the radon-related lung cancer risk is evaluated. The excess relative risk (ERR) per working level month (WLM) was estimated as 0.21% (95% CI: 0.18-0.24). It was dependent on time since exposure and on attained age. The highest ERR/WLM was observed 15-24 years after exposure and in the youngest age group (< 55 years of age). While a strong inverse exposure-rate effect was detected for high exposures, no significant association was detected at exposures below 100 WLM. Excess relative risk/WLM was not modified by duration of exposure. The results would indicate the need to re-estimate the effects of risk modifying factors in current risk models as duration of exposure did not modify the ERR/WLM and there was only a modest decline of ERR/WLM with increasing time since exposure.