Sensorimotor polyneuropathy associated with chronic lymphocytic leukemia, IgM antigangliosides antibody and human T‐cell leukemia virus I infection
Sensorimotor polyneuropathy associated with chronic lymphocytic leukemia, IgM antigangliosides antibody and human T‐cell leukemia virus I infection
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与慢性淋巴细胞白血病、IgM 抗神经节苷脂抗体和人 T 细胞白血病病毒 I 感染相关的感觉运动性多发性神经病
作者：
Y. Mitsui;S. Kusunoki;S. Hiruma;Maiko Akamatsu;M. Kihara;Shigeo Hashimoto;M. Takahashi
一名 65 岁男性患有与 B 细胞慢性淋巴细胞白血病 (CLL) 和针对各种神经节苷脂的免疫球蛋白 M (IgM) 抗体相关的感觉运动性多发性神经病。电生理学研究表明运动和感觉神经传导存在显着异常。尽管腓肠神经活检的病理学看起来受影响最小，但免疫组织化学研究显示 IgM 与人类周围神经特异性结合。该患者的血清和脑脊液 (CSF) 中也存在高滴度的人 T 细胞白血病病毒 I (HTLV-I) 抗体，这可能会激活 B 细胞介导的免疫并促进 IgM 抗体的产生。另一个独特的特征是抗体对神经节苷脂的反应性。患者对具有二唾液酸残基的神经节苷脂（例如 GT1b、GQ1b 和 GD3）有 IgM 抗体反应性，但对 GD1b 没有反应性。据报道，共济失调症状中存在带有二唾液酸残基的神经节苷脂的 IgM 抗体，但我们的患者未能表现出共济失调。如果没有对 GD1b 的反应性，即使存在与其他具有二唾液酸残基的神经节苷脂发生反应的抗体，感觉性共济失调神经病也可能不会发生。 © 1999 John Wiley & Sons, Inc. 肌肉神经 22：1461–1465，1999
A 65‐year‐old man presented with a sensorimotor polyneuropathy associated with B‐cell chronic lymphocytic leukemia (CLL) and immunoglobulin M (IgM) antibody to various gangliosides. Electrophysiological studies denoted significant abnormalities of motor and sensory nerve conduction. Although the pathology of sural nerve biopsy looked minimally affected, immunohistochemical studies showed specific binding of IgM to the human peripheral nerve. Our patient also had high titer of antibody to human T‐cell leukemia virus I (HTLV‐I) in both serum and cerebrospinal fluid (CSF), which might activate B‐cell–mediated immunity and facilitate the production of IgM antibody. The other unique feature is the reactivity of antibody to gangliosides. The patient had IgM antibody reactivities to gangliosides with disialosyl residue such as GT1b, GQ1b and GD3, but not to GD1b. IgM antibody to gangliosides with disialosyl residue has been reported in ataxic symptoms, but our patient failed to demonstrate ataxia. Without reactivity to GD1b, sensory ataxic neuropathy might not develop even in the presence of antibody reactive to other gangliosides with disialosyl residue. © 1999 John Wiley & Sons, Inc. Muscle Nerve 22: 1461–1465, 1999
神经病患者中含有糖脂的硫酸化葡萄糖醛酸与 IgM M 蛋白反应的表征。
DOI：
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发表时间：
1987
期刊：
The Journal of biological chemistry
影响因子：
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作者：
Ariga,T;Kohriyama,T;Freddo,L;Latov,N;Saito,M;Kon,K;Ando,S;Suzuki,M;Hemling,ME;RinehartJr,KL
通讯作者：
RinehartJr,KL
神经病中的单克隆抗 DNA IgM kappa 与髓磷脂以及磷脂酸和神经节苷脂形成的构象表位结合。
DOI：
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发表时间：
1986
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Freddo,L;Hays,AP;Nickerson,KG;Spatz,L;McGinnis,S;Lieberson,R;Vedeler,CA;Shy,ME;Autilio-Gambetti,L;Grauss,FC
通讯作者：
Grauss,FC