Control of abdominal and expiratory intercostal muscle activity during vomiting: role of ventral respiratory group expiratory neurons.
Control of abdominal and expiratory intercostal muscle activity during vomiting: role of ventral respiratory group expiratory neurons.
复制标题
呕吐期间腹部和呼气肋间肌活动的控制：腹侧呼吸组呼气神经元的作用。
DOI：
10.1152/jn.1987.57.6.1854
复制
发表时间：
1987
影响因子：
2.5
通讯作者：
Suzuki,I
中科院分区：
文献类型：
--
作者：
Miller,AD;Tan,LK;Suzuki,I
通过记录麻痹动物呕吐时腹侧呼吸组（VRG）呼气(E)神经元在呕吐时腹部和肋间（呼气）肌活动中的作用，并比较这些下行神经元轴突切片前后呕吐时腹部肌肉活动，研究了腹侧呼吸组（VRG）呼气(E)神经元在呕吐期间的控制作用。假性呕吐的定义是由膈下迷走神经刺激或催吐药物引起的一系列腹神经和膈神经的共同激活。如果动物没有瘫痪，这种协同活动预计会导致呕吐。从下胸（T13）或腰椎脊髓逆行激活的27个VRG E神经元记录数据。在假性呕吐期间，几乎三分之二的神经元（17/27）主要活跃在腹神经和膈神经共激活之间，此时已知肋间内运动神经元是活跃的。这组神经元被称为INT神经元。根据每一次膈神经和腹神经共激活之间（INTa神经元，n = 10）或仅在某些爆发之间（INTb神经元，n = 7），对INT神经元进行细分。另外三分之一的VRG E神经元在腹部神经活跃时（ABD神经元）的活动水平正常或增加。剩下的一个神经元在呕吐过程中基本保持沉默。ABD神经元与INT神经元在VRG中的位置、放电模式类型（斜向与阶梯斜向）、传导速度或腰束投射范围难以区分。然而，在呼吸过程中，INTa神经元的放电率明显高于ABD或INTb神经元。我们记录了6只未瘫痪猫的腹肌肌电图和神经活动，在切断VRG E神经元轴突穿过C1和肥胖之间的中线之前和之后。病变消除或几乎消除了腹肌活动的呼气调节。相反，腹部肌肉在呕吐时总是活跃的；然而，病变后腹部活动的幅度从三只猫的病变前值的大约70-100%到第四只猫的正常值的60-70%到另外两只猫的病变前值的大约20%不等。（摘要删节为400字）
The role of ventral respiratory group (VRG) expiratory (E) neurons in the control of abdominal and internal intercostal (expiratory) muscle activity during vomiting was examined in decerebrate cats by recording from these neurons during fictive vomiting in paralyzed animals and comparing abdominal muscle activity during vomiting before and after sectioning the axons of these descending neurons. Fictive vomiting was defined by a series of bursts of coactivation of abdominal and phrenic nerves elicited by either subdiaphragmatic vagus nerve stimulation or emetic drugs. Such coordinated activity would be expected to produce vomiting if the animals were not paralyzed. Data were recorded from 27 VRG E neurons that were antidromically activated from the lower thoracic (T13) or lumbar spinal cord. During fictive vomiting, almost two-thirds of these neurons (17/27) were mainly active in between periods of abdominal and phrenic nerve coactivation, when the internal intercostal motoneurons are known to be active. This group of neurons was termed INT neurons. INT neurons were subdivided according to whether they were active between every burst of phrenic and abdominal nerve coactivation (INTa neurons, n = 10) or only between some bursts (INTb neurons, n = 7). Another one-third of the VRG E neurons had normal or increased levels of activity when the abdominal nerves were active during fictive vomiting (ABD neurons). The one remaining neuron was mainly silent throughout fictive vomiting. ABD neurons were indistinguishable from INT neurons on the basis of their location in the VRG, type of firing pattern (ramp versus step ramp), conduction velocity, or extent of projection in the lumbar cord. However, INTa neurons had a significantly higher discharge rate during respiration than either ABD or INTb neurons. Abdominal muscle EMG and nerve activity were recorded from six unparalyzed cats before and after cutting the axons of VRG E neurons as they cross the midline between C1 and the obex. The lesions abolished or almost eliminated expiratory modulation of abdominal muscle activity. In contrast, the abdominal muscles were always active during vomiting; however, the amplitude of postlesion abdominal activity varied from approximately 70-100% of prelesion values in three cats to 60-70% of normal in a fourth animal to only approximately 20% of prelesion values in two other cats.(ABSTRACT TRUNCATED AT 400 WORDS)