G protein-coupled receptor signalling in in vivo cardiac overload
G protein-coupled receptor signalling in in vivo cardiac overload
复制标题
DOI：
10.1046/j.1365-201x.2001.00884.x
复制
发表时间：
2001-09-01
期刊：
影响因子：
--
通讯作者：
Rockman, HA
中科院分区：
文献类型：
--
作者：
Rapacciuolo, A;Esposito, G;Rockman, HA
心肌细胞通过启动导致肥大的细胞过程来响应生物力学应力。虽然心脏肥大是对心脏压力增加的反应，但它与血浆儿茶酚胺水平升高和心脏发病率和死亡率增加有关。了解引发肥厚反应的细胞信号对于确定肥厚心脏的不适应恶化到心力衰竭的途径至关重要。本文将重点介绍G蛋白偶联受体在心脏信号通路激活中的作用，如丝裂原活化蛋白激酶和磷酸肌醇-3激酶途径。
Cardiac myocytes respond to biomechanical stress by initiating cellular processes that lead to hypertrophy. Although cardiac hypertrophy is a response to increased stress on the heart, it is associated with elevated plasma catecholamine levels and an increase in cardiac morbidity and mortality. Understanding the cellular signals that initiate the hypertrophic response will be of critical importance to identify pathways that mediate the maladaptive deterioration of the hypertrophic heart to one of cardiac failure. This review will focus on the role of G protein-coupled receptors in the activation of signalling pathways in the heart, such as the mitogen activated protein kinase and phosphoinositide-3 kinase pathways.