Plasma-cell dyscrasia and peripheral neuropathy with a monoclonal antibody to peripheral-nerve myelin.
Plasma-cell dyscrasia and peripheral neuropathy with a monoclonal antibody to peripheral-nerve myelin.
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周围神经髓磷脂单克隆抗体可治疗浆细胞恶液质和周围神经病变。
DOI：
10.1056/nejm198009113031105
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
E. Osserman
中科院分区：
文献类型：
--
作者：
N. Latov;W. Sherman;R. Nemni;G. Galassi;J. Shyong;A. Penn;L. Chess;M. Olarte;L. Rowland;E. Osserman
周围神经病变与浆细胞恶液质有关1，但尚不清楚单克隆免疫球蛋白是否与周围神经抗原发生反应。我们报道了一名患有与 IgMk 单克隆蛋白相关的周围神经病变的患者，该患者的病理学和免疫学研究表明，IgMk 抗体针对周围神经髓磷脂，如补体结合和免疫吸收所示。病例报告 该患者是一名 45 岁男性，因评估持续 11 年的缓慢进行性感觉运动神经病而入院。检查发现手和远端肌肉中度至重度无力和萎缩。 。 。
PERIPHERAL neuropathy has been associated with plasma-cell dyscrasia, 1 but it is not known whether the monoclonal immunoglobulins react with peripheral-nerve antigens. We report on a patient with a peripheral neuropathy associated with an IgMk monoclonal protein, in whom pathological and immunological studies indicated that the IgMk antibody was directed against peripheral-nerve myelin, as shown by complement fixation and immunoabsorption. Case Report The patient was a 45-year-old man admitted for evaluation of a slowly progressive sensory-motor neuropathy of 11 years' duration. On examination there was moderate to severe weakness and atrophy of the muscles of the hands and distal parts of . . .