Plasmodium yoelii Can Ablate Vaccine-Induced Long-Term Protection in Mice1
Plasmodium yoelii Can Ablate Vaccine-Induced Long-Term Protection in Mice1
复制标题
约氏疟原虫可以消除疫苗诱导的小鼠长期保护作用1
DOI：
10.4049/jimmunol.175.4.2510
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
M. Good
中科院分区：
文献类型：
--
作者：
M. Wykes;Yong;X. Liu;M. Good
疟疾是流行地区居民发病和死亡的严重原因，但与许多其他感染不同的是，接触这种寄生虫的人不会迅速对后续感染产生抵抗力。在模型系统中，针对裂殖子表面蛋白-1的19 kDa C末端片段的高滴度抗体可以介导完全保护；然而，以前的研究尚未确定该疫苗是否产生长期保护。在这项研究中，我们报告由裂殖子表面蛋白-1产生的功能记忆细胞本身不提供任何保护。这是因为这种寄生虫会导致疫苗特有的记忆B细胞以及长寿的浆细胞的缺失，包括那些针对旁观者免疫反应的细胞。我们的研究证明了一种新的机制，通过这种机制，疟原虫可以消除疫苗的免疫记忆，从而使宿主的免疫功能受损。
Malaria is a serious cause of morbidity and mortality for people living in endemic areas, but unlike many other infections, individuals exposed to the parasite do not rapidly become resistant to subsequent infections. High titers of Ab against the 19-kDa C-terminal fragment of the merozoite surface protein-1 can mediate complete protection in model systems; however, previous studies had not determined whether this vaccine generated long-term protection. In this study, we report that functional memory cells generated by merozoite surface protein-1, per se, do not offer any protection. This is because the parasite induces deletion of vaccine-specific memory B cells as well as long-lived plasma cells including those specific for bystander immune responses. Our study demonstrates a novel mechanism by which Plasmodium ablates immunological memory of vaccines, which would leave the host immuno-compromised.
影响因子：
32.4
作者：
Slifka, MK;Antia, R;Ahmed, R
通讯作者：
Ahmed, R