Expression of the T-cell activation antigen, OX-40, identifies alloreactive T cells in acute graft-versus-host disease
Expression of the T-cell activation antigen, OX-40, identifies alloreactive T cells in acute graft-versus-host disease
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DOI：
10.1182/blood.v89.12.4652
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发表时间：
1997-06-15
期刊：
影响因子：
20.3
通讯作者：
Maziarz, RT
中科院分区：
文献类型：
--
作者：
Tittle, TV;Weinberg, AD;Maziarz, RT
OX-40分子在最近活化的T淋巴细胞表面表达。（亲本-> F1）急性移植物抗宿主病（aGVHD）的骨髓移植模型，表达OX-的活化CD 4（+）T细胞数量增加移植后不久，在最早的疾病迹象之前，在外周血中检测到40抗原。OX-40表达的峰值出现在移植后12天，范围为循环T细胞的18%至36%，并保持在背景以上10倍，从未恢复到基线。（范围，1%至6%）也在来自对照同基因F1-> F1受体的外周血淋巴细胞上检测到，OX-40（+）T细胞分离自经历aGVHD的大鼠的脾、皮肤、淋巴结、末端肝组织，但不在同基因移植中，从这些组织分离的OX-40（+）T细胞是供体来源的并且显示为同种异体反应性的，这些数据提高了使用OX-40抗体来检测和选择性地消耗导致aGVHD的T细胞的可能性。(C)1997年，美国血液学会。
The OX-40 molecule is expressed on the surface of recently activated T lymphocytes, The presence of OX-40 on CD4(+) T cells was analyzed in a rat haplo-identical (parental --> F1) bone marrow transplant model of acute graft-versus-host disease (aGVHD), Increased numbers of activated CD4(+) T cells that expressed the OX-40 antigen were detected in peripheral blood soon after transplantation before the earliest sign of disease. The peak of OX-40 expression occurred 12 days posttransplantation with a range of 18% to 36% of circulating T cells and remained 10-fold above background, never returning to baseline, A slight increase in OX-40 expression (range, 1% to 6%) was also detected on peripheral blood lymphocytes from control syngeneic Fl --> Fl recipients, OX-40(+) T cells were isolated from spleen, skin, lymph node, end liver tissue of rats undergoing aGVHD, but not in syngeneic transplants, OX-40(+) T cells isolated from these tissues were of donor origin and were shown to be alloreactive, These data raise the possibility of using the OX-40 antibody to detect and deplete selectively the T cells that cause aGVHD. (C) 1997 by The American Society of Hematology.