Piperlongumine Suppresses Dendritic Cell Maturation by Reducing Production of Reactive Oxygen Species and Has Therapeutic Potential for Rheumatoid Arthritis
Piperlongumine Suppresses Dendritic Cell Maturation by Reducing Production of Reactive Oxygen Species and Has Therapeutic Potential for Rheumatoid Arthritis
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Piperlongumine 通过减少活性氧的产生来抑制树突状细胞成熟，并具有治疗类风湿关节炎的潜力
DOI：
10.4049/jimmunol.1501281
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发表时间：
2016-06
影响因子：
4.4
通讯作者：
Xu Hanshi
中科院分区：
文献类型：
--
作者：
Xiao Youjun;Shi Maohua;Qiu Qian;Huang Mingcheng;Zeng Shan;Zou Yaoyao;Zhan Zhongping;Liang Liuqin;Yang Xiuyan;Xu Hanshi
Piperlongumine (PLM) is a natural product from the plant Piper longum that inhibits platelet aggregation, atherosclerosis plaque formation, and tumor cell growth. It has potential value in immunomodulation and the management of autoimmune diseases. In this study, we investigated the role of PLM in regulating the differentiation and maturation of dendritic cells (DCs), a critical regulator of immune tolerance, and evaluated its clinical effects in a rheumatoid arthritis mouse model. We found that PLM treatment reduced LPS-induced murine bone marrow–derived DC maturation, characterized by reduced expression of CD80/86, secretion of MCP-1, IL-12p70, IL-6, TNFα, IFN-γ, and IL-23, and reduced alloproliferation of T cells; however, PLM does not affect cell differentiation. Furthermore, PLM reduced intracellular reactive oxygen species (ROS) production by DCs and inhibited the activation of p38, JNK, NF-κB, and PI3K/Akt signaling pathways. Conversely, PLM increased the expression of GSTP1 and carbonyl reductase 1, two enzymes that counteract ROS effects. ROS inhibition by exogenous N-acetyl-l-cysteine suppressed DC maturation. PLM treatment improved the severity of arthritis and reduced in vivo splenic DC maturation, collagen-specific CD4+ T cell responses, and ROS production in mice with collagen-induced arthritis. Taken together, these results suggest that PLM inhibits DC maturation by reducing intracellular ROS production and has potential as a therapeutic agent for rheumatoid arthritis.
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影响因子：
4.9
作者：
Cavanagh LL;Boyce A;Smith L;Padmanabha J;Filgueira L;Pietschmann P;Thomas R
通讯作者：
Thomas R
影响因子：
64.8
作者：
Sakaguchi, N;Takahashi, T;Sakaguchi, S
通讯作者：
Sakaguchi, S
影响因子：
15.9
作者：
Abdollahi-Roodsaz, Shahla;Joosten, Leo A. B.;Van den Berg, Wim B.
通讯作者：
Van den Berg, Wim B.
影响因子：
2.1
作者：
CHATTERJEE, A;DUTTA, CP
通讯作者：
DUTTA, CP
Piperlongumine 通过活性氧积累依赖的 JNK 和 p38 激活选择性杀死多形性胶质母细胞瘤细胞
DOI：
10.1016/j.bbrc.2013.06.042
发表时间：
2013-07-19
影响因子：
3.1
作者：
Liu, Ju Mei;Pan, Feng;Chen, Xiao Qian
通讯作者：
Chen, Xiao Qian