EFFECTS OF CHEMOTHERAPEUTIC-AGENTS ON BONE .1. SHORT-TERM METHOTREXATE AND DOXORUBICIN (ADRIAMYCIN) TREATMENT IN A RAT MODEL
EFFECTS OF CHEMOTHERAPEUTIC-AGENTS ON BONE .1. SHORT-TERM METHOTREXATE AND DOXORUBICIN (ADRIAMYCIN) TREATMENT IN A RAT MODEL
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DOI：
10.2106/00004623-198466040-00016
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发表时间：
1984-01-01
影响因子：
5.3
通讯作者：
BARON, R
中科院分区：
文献类型：
--
作者：
FRIEDLAENDER, GE;TROSS, RB;BARON, R
Wistar-Lewis rats received therapeutic doses of doxorubicin or methotrexate daily for 5 days, were pulse-labeled with a fluorescent compound (calcein) on the 7th and 13th days, were killed 14 days after initiation of the protocol. Proximal tail vertebrae were then evaluated histomorphometrically, and the effects of the chemotherapeutic agents on trabecular bone were quantitated with respect to changes in total bone mass, new-bone formation and resorption. Short-term administration of methotrexate caused a 26.9% reduction in net trabecular bone volume and doxorubicin, an 11.5% decrease. Both drugs significantly and profoundly diminished bone-formation rates by nearly 60%. The toxic effect on osteoblasts was also reflected in reduced volume and thickness of osteoid, but the total numbers of osteoblasts and the percent of trabecular surface covered by bone-forming cells were not affected. The numbers of osteoclasts and the extent of their activity were not clearly different from those in untreated rats, but rates of resorption were not determined. The effects of chronic treatment with these chemotherapeutic agents on intact, fractured and transplanted bone and the biochemical significance of these changes has not yet been evaluated.
