Insensitivity of Adipocytes of Hypophysectomized Rats to Growth Hormone and Insulin 1
Insensitivity of Adipocytes of Hypophysectomized Rats to Growth Hormone and Insulin 1
复制标题
垂体切除大鼠脂肪细胞对生长激素和胰岛素1的不敏感性
DOI：
10.3181/00379727-137-35537
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发表时间：
1971
影响因子：
--
通讯作者：
H. Goodman
中科院分区：
文献类型：
--
作者：
R. Eastman;H. Goodman
摘要： 当暴露于胰岛素或生长激素时，通过用胶原酶消化从垂体切除的大鼠的附睾脂肪制备的游离脂肪细胞未能表现出增加的葡萄糖氧化。来自同一垂体切除大鼠的附睾脂肪片段对这些激素反应正常。当从正常大鼠身上获得时，附睾脂肪和游离脂肪细胞的两段也表现出对胰岛素的正常敏感性。通过缩短消化时间、添加胰蛋白酶或磷脂酶抑制剂或用可的松、三碘甲状腺原氨酸或生长激素预处理供体动物，垂体切除动物的脂肪细胞的激素反应性并未恢复。
Summary Free fat cells prepared from epididymal fat of hypophysectomized rats by digestion with collagenase failed to exhibit increased glucose oxidation when exposed to insulin or growth hormone. Segments of epididymal fat from the same hypophysectomized rats responded normally to these hormones. When obtained from normal rats, both segments of epididymal fat and free adipocytes also exhibited normal sensitivity to insulin. Hormonal responsiveness of adipose cells of hypophysectomized animals was not restored by shortening the digestion period, addition of trypsin or phospholipase inhibitors or pretreatment of the donor animals with cortisone, triiodothyronine, or growth hormone.