New QTL for resistance to Salmonella carrier-state identified on fowl microchromosomes
New QTL for resistance to Salmonella carrier-state identified on fowl microchromosomes
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DOI：
10.1007/s00438-011-0600-9
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发表时间：
2011-03-01
影响因子：
3.1
通讯作者：
Beaumont, Catherine
中科院分区：
文献类型：
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作者：
Calenge, Fanny;Vignal, Alain;Beaumont, Catherine
鸡携带沙门氏菌而不显示疾病症状的能力导致沙门氏菌在家禽库存中无形地传播。使用对带菌者状态更有抵抗力的鸡品系可以改善动物健康和食品安全。先前的研究鉴定了几个抗携带状态的QTL。为了提高基因组覆盖率和QTL检测能力，我们产生了一组新的480个信息SNP标记，并对大量动物进行了基因分型。与以前的研究相比，可以覆盖10个额外的微染色体。这些新的数据导致18个QTL的鉴定显着的染色体水平。在全基因组水平上唯一显著的QTL在微染色体14和22上鉴定，并且以前从未鉴定过。使用更多数量的动物提高了QTL检测的功效和精度。一些新发现的QTL位于候选基因或微卫星标记之前确定的参与对沙门氏菌的抗性的遗传控制，这证实了他们的选择目的的兴趣。
Chicken's ability to carry Salmonella without displaying disease symptoms leads to an invisible propagation of Salmonella in poultry stocks. Using chicken lines more resistant to carrier state could improve both animal health and food safety. Previous studies identified several QTL for resistance to carrier state. To improve genome coverage and QTL detection power we produced a new set of 480 informative SNP markers and genotyped a larger number of animals. Ten additional microchromosomes could be covered when compared with previous studies. These new data led to the identification of 18 QTL significant at the chromosome-wide level. The only QTL significant at the genome-wide level were identified on microchromosomes 14 and 22 and have never been identified previously. Using a higher number of animals improved the power and the precision of QTL detection. Some of the QTL newly identified are located close to candidate genes or microsatellite markers previously identified for their involvement in the genetic control of resistance to Salmonella, which confirms their interest for selection purposes.