An experimental evaluation of tic suppression and the tic rebound effect
An experimental evaluation of tic suppression and the tic rebound effect
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DOI：
10.1016/j.brat.2004.11.002
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发表时间：
2005-11-01
影响因子：
4.1
通讯作者：
Woods, DW
中科院分区：
文献类型：
--
作者：
Himle, MB;Woods, DW
图雷特综合症（TS）是一种神经生物学障碍，由运动和声音抽搐组成，被认为是暂时抑制的。然而，许多专业人士认为，当抑制的努力停止时，抽动频率会出现矛盾的增加（高于基线水平）（即反弹效应）。迄今为止，很少有研究调查抽动抑制或其影响。本研究检查了基线、抑制和抑制后条件下的抽动频率，使用一种实验制剂，据报道可以可靠地抑制儿童的抽动。6名TS患儿和1名慢性抽动障碍（CTD）患儿在基线、重复抑制和后抑制条件下进行了记录。与基线相比，抑制期间Tic频率显著降低。尽管抑制后的抽动频率高于抑制期间，但低于基线水平，反对抽动抑制的“反弹”效应。探索性分析显示，儿童行为检查表中注意问题分量表得分显著预测抽动抑制。年龄，抽动严重程度和抽动抑制之间的关系也进行了探讨。(c) 2005 Elsevier Ltd版权所有。
Tourette's syndrome (TS) is a neurobiological disorder consisting of motor and vocal tics that are thought to be temporarily suppressible. Many professionals, however, believe that a paradoxical increase in tic frequency (above baseline levels) occurs when efforts to suppress have ceased (i.e., a rebound effect). To date, little research has investigated tic suppression or its effects. This study examined tic frequency during baseline, suppression, and post-suppression conditions using an experimental preparation reported to reliably produce tic suppression in children. Six children with TS and one with chronic tic disorder (CTD) were recorded during baseline and repeated suppression and post-suppression conditions. Tic frequency was significantly lower during suppression as compared to baseline. Although tic frequency during post-suppression was higher than during suppression, it was lower than baseline levels, arguing against a "rebound" effect of tic suppression. Exploratory analyses revealed that scores on the attention problems subscale of the Child Behavior Checklist significantly predicted tic suppressibility. The relationships between age, tic severity, and tic suppressibility were also explored. (c) 2005 Elsevier Ltd. All rights reserved.