Memantine reduces functional and morphological consequences induced by global ischemia in rats
Memantine reduces functional and morphological consequences induced by global ischemia in rats
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DOI：
10.1016/0304-3940(96)12545-3
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发表时间：
1996-04-12
影响因子：
2.5
通讯作者：
Schwarz, M
中科院分区：
文献类型：
--
作者：
Block, F;Schwarz, M
在这项研究中，美金刚，在N-甲基-D-天冬氨酸受体拮抗剂，对空间的影响。评价了短暂性脑缺血后的学习缺陷和神经元损伤。采用四血管闭塞法（4VO）造成大鼠全脑缺血20 min。在诱导缺血前20分钟以10或20 mg/kg的剂量给予美金刚。术后一周在Morris水迷宫中测试空间学习。高剂量美金刚胺治疗可减少4VO引起的逃避潜伏期和游泳距离的增加。20 mg/kg美金刚胺可显著减弱4VO引起的海马CA 1区和纹状体神经元损伤。低剂量的美金刚胺对缺血引起的空间学习障碍和神经元损伤没有影响。目前的数据表明，用神经保护剂如美金刚胺治疗可以减少缺血引起的功能和形态学后遗症。
In this study the effect of memantine, an antagonist at the N-methyl-D-aspartate receptor, on spatial. learning deficit and on neuronal damage following transient cerebral ischemia was evaluated. Global ischemia was induced by four-vessel-occlusion (4VO) for 20 min in rats. Memantine was administered 20 min before induction of ischemia at a dose of 10 or 20 mg/kg. One week after surgery spatial learning was tested in the Morris water maze. Treatment with the higher dose of memantine reduced the increase in escape latency and in swim distance induced by 4VO. Neuronal damage in the CA1 sector of the hippocampus and in the striatum produced by 4VO was significantly attenuated by 20 mg/kg memantine. Treatment with the lower dose of memantine had no influence on the deficit in spatial learning and the neuronal damage resulting from ischemia. The present data demonstrate that treatment with a neuroprotective agent like memantine can reduce functional as well as morphological sequelae induced by ischemia.