Decarbonylative Coupling of α-Keto Acids and Ynamides for Synthesis of β-Keto Imides
Decarbonylative Coupling of α-Keto Acids and Ynamides for Synthesis of β-Keto Imides
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DOI：
10.1021/acs.orglett.8b01302
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发表时间：
2018-06-01
期刊：
影响因子：
5.2
通讯作者：
Cui, Sunliang
中科院分区：
文献类型：
--
作者：
Chen, Renjie;Zeng, Linwei;Cui, Sunliang
报道了一种新型的 α-酮酸和 ynamides 脱羰偶联，通过 CO 挤出合成 β-酮酰亚胺。该工艺具有反应条件温和、底物范围广、效率高等特点。进行同位素标记反应和 GC 分析以阐明合理的反应机制。
A novel decarbonylative coupling of alpha-keto acids and ynamides with extrusion of CO for synthesis of beta-keto imides is reported. This process features mild reaction conditions, a broad substrate scope, and high efficiency. An isotope-labeling reaction and GC analysis were conducted to elucidate a plausible reaction mechanism.