FAMILY-GENETIC AND PSYCHOSOCIAL RISK-FACTORS IN DSM-III ATTENTION DEFICIT DISORDER
FAMILY-GENETIC AND PSYCHOSOCIAL RISK-FACTORS IN DSM-III ATTENTION DEFICIT DISORDER
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DOI：
10.1097/00004583-199007000-00004
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发表时间：
1990-07-01
影响因子：
13.3
通讯作者：
TSUANG, MT
中科院分区：
文献类型：
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作者：
BIEDERMAN, J;FARAONE, SV;TSUANG, MT
采用家庭研究方法和盲评者的评估，本研究对临床转诊的儿童和青少年ADD （N = 73）的457名一级亲属进行了DSM-III注意缺陷障碍（ADD）的家庭遗传和社会心理危险因素的评估，并与精神病患者（N = 26）和正常对照组（N = 26）进行了比较。ADD先证亲属患ADD（25.1%比5.3%比4.6%,ps < 0.00001）、反社会障碍（25.3%比6.9%比4.2%,ps < 0.00001）和情绪障碍（27.1%比13.9%,p = 0.038和27.1%比3.6%,p = 0.00001）的风险高于精神病和正常对照亲属。ADD风险的增加不能用性别或亲属代际、先证者的年龄、社会阶层或家庭的完整性来解释。这些结果证实并扩展了先前的发现，即adhd的重要家族遗传风险因素。
Using family study methodology and assessments made by blind raters, this study evaluated family-genetic and psychosocial risk factors for DSM-III attention deficit disorder (ADD) among the 457 first-degree relatives of clinically referred children and adolescents with ADD (N = 73), compared with psychiatric (N = 26) and normal controls (N = 26). Relatives of ADD probands had a higher morbidity risk for ADD (25.1% versus 5.3% versus 4.6%, ps < 0.00001), antisocial disorders (25.3% versus 6.9% versus 4.2%, ps < 0.00001), and mood disorders (27.1% versus 13.9%, p = 0.038 and 27.1% versus 3.6%, p = 0.00001) than did relatives of psychiatric and normal controls. The increased risk for ADD could not be accounted for by gender or generation of relative, the age of proband, social class, or the intactness of the family. These results confirm and extend previous findings indicating important family-genetic risk factors in ADD.