LIGHT-PULSES THAT SHIFT RHYTHMS INDUCE GENE-EXPRESSION IN THE SUPRACHIASMATIC NUCLEUS
LIGHT-PULSES THAT SHIFT RHYTHMS INDUCE GENE-EXPRESSION IN THE SUPRACHIASMATIC NUCLEUS
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DOI：
10.1126/science.2112267
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发表时间：
1990-06-08
期刊：
影响因子：
56.9
通讯作者：
HUNT, SP
中科院分区：
文献类型：
--
作者：
RUSAK, B;ROBERTSON, HA;HUNT, SP
光照周期通过改变下丘脑视交叉上核（SCN）细胞的活动来同步（引导）哺乳动物的昼夜节律，视交叉上核是昼夜节律起搏器。将仓鼠和大鼠暴露在昼夜节律阶段的光脉冲中，在此期间，光可以改变节奏，导致接收视网膜纤维的SCN区域细胞中立即早期基因c-fos产物的免疫反应性增加。光脉冲也增加了大鼠SCN中Fos蛋白和NGFI-A蛋白的信使RNA。在仓鼠的SCN中，NGFI-A mRNA也出现了类似的增加。因此，SCN这部分的细胞在视网膜照明下会发生基因表达的改变，但这只是在昼夜周期中光线能够影响夹带的时候。
Lighting cycles synchronize (entrain) mammalian circadian rhythms by altering activity of cells in the suprachiasmatic nucleus (SCN) of the hypothalamus, a circadian pacemaker. Exposure to hamsters and rats to light pulses at those phases of the circadian rhythm during which light can shift the rhythm caused increased immunoreactivity for the product of the immediate-early gene c-fos in cells in the region of the SCN that receives retinal fibers. Light pulses also increased messenger RNA for the Fos protein and for the immediate-early protein NGFI-A in the rat SCN. Similar increases in mRNA for NGFI-A were seen in the SCN of hamsters. Thus cells in this portion of the SCN undergo alterations in gene expression in response to retinal illumination, but only at times in the circadian cycle when light is capable of influencing entrainment.