Vasodilator profile of synthetic atrial natriuretic factor.
Vasodilator profile of synthetic atrial natriuretic factor.
复制标题
合成心房钠尿因子的血管扩张剂概况。
DOI：
10.1016/0014-2999(84)90353-4
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发表时间：
1984
影响因子：
5
通讯作者：
R. Nutt
中科院分区：
文献类型：
--
作者：
R. Winquist;E. Faison;R. Nutt
合成心钠素（ANF）的血管舒张作用特点是使用离体血管制备。纳摩尔浓度的心钠素松弛兔主动脉环收缩的血清素，组胺，甲氧胺或血管紧张素II。合成肽在放松家兔面部静脉的紧张性内在收缩方面最有效（IC 50 = 1.3 × 10− 10 M）。ANF对K+收缩的主动脉环或大鼠门静脉的阶段性收缩的活性较差。硝普钠具有类似的血管扩张作用，但罂粟碱、肼苯哒嗪、腺苷或硝苯地平则没有。合成ANF的血管活性的首次证明将这种物质描述为激动剂诱导的收缩的非选择性血管扩张剂。ANF和硝普钠的血管扩张活性的相似性表明了共同的作用机制。
The vasodilator profile of synthetic atrial natriuretic factor (ANF) was characterized using isolated vascular preparations. Nanomolar concentrations of ANF relaxed rabbit aortic rings contracted by serotonin, histamine, methoxamine or angiotensin II. The synthetic peptide was most effective (IC50= 1.3 × 10−10M) in relaxing the tonic, intrinsic contractions of the rabbit facial vein. ANF was poorly active against K+-contracted aortic rings or the phasic contractions of the rat portal vein. A similar vasodilator profile was obtained for sodium nitroprusside but not papaverine, hydralazine, adenosine or nifedipine. This first demonstration of the vascular activity of synthetic ANF depicts this substance as a nonselective vasodilator of agonist-induced contractions. The observed similarities in the vasodilator activity of ANF and sodium nitroprusside suggest a common mechanism of action.