MOTOR DEFICIT AND IMPAIRMENT OF SYNAPTIC PLASTICITY IN MICE LACKING MGLUR1
MOTOR DEFICIT AND IMPAIRMENT OF SYNAPTIC PLASTICITY IN MICE LACKING MGLUR1
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DOI：
10.1038/372237a0
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发表时间：
1994-11-17
期刊：
影响因子：
64.8
通讯作者：
CREPEL, F
中科院分区：
文献类型：
--
作者：
CONQUET, F;BASHIR, ZI;CREPEL, F
代谢型谷氨酸受体1 （mGluR1）是g蛋白偶联谷氨酸受体大家族的一员，其生理功能在很大程度上是未知的。缺乏mGluR1的小鼠有严重的运动协调和空间学习缺陷。它们在小脑或海马中没有明显的解剖或基本的电生理异常，但它们表现出小脑长期抑郁和海马杂乱纤维长期增强受损，因此mglur1缺陷小鼠应该是研究突触可塑性的有价值的模型。
Metabotropic glutamate receptor 1 (mGluR1) is a member of a large family of G-protein-coupled glutamate receptors, the physiological functions of which are largely unknown. Mice deficient in mGluR1 have severe motor coordination and spatial learning deficits. They have no gross anatomical or basic electrophysiological abnormalities in either the cerebellum or hippocampus, but they show impaired cerebellar long-term depression and hippocampal messy fibre long-term potentiation, mGluR1-deficient mice should therefore be valuable models for studying synaptic plasticity.