n-3 fatty acids and the inflammatory response - biological background
n-3 fatty acids and the inflammatory response - biological background
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DOI：
10.1016/s1520-765x(01)90118-x
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发表时间：
2001-06-01
影响因子：
1.6
通讯作者：
Basta, G
中科院分区：
文献类型：
--
作者：
De Caterina, R;Basta, G
炎症可以定义为活的血管化组织对局部损伤的反应，并且在疾病的正常修复反应和发病机制中起作用。炎症现象是几乎任何全身性或器官特异性疾病中的许多疾病过程的基础，所述疾病的范围从经典风湿性疾病到支气管气道高反应性、炎症性肠病、肾病、牛皮癣和特应性湿疹。调节长链多不饱和脂肪酸的摄入，主要是通过增加n-3与n-6脂肪酸的相对比例，是饮食如何调节炎症过程的最明显的例子。不同人群中炎症性疾病发病率的许多可归因于环境的流行病学差异可能可以追溯到所选的、定量的次要营养成分（如ω-3脂肪酸）的不同营养摄入。这些化合物的饮食摄入量的增加或其药理学补充导致炎症反应的适度淬灭，这可能证明在选定的临床病症中有用。澄清这些以及其他饮食成分的生物作用机制，以及更好地记录饮食操纵摄入此类化合物所提供的临床可能性谱，将经典营养科学，分子生物学，流行病学和临床医学联系在一起，是未来几年营养研究的前沿。这种营养方法有望在某些炎症性疾病的治疗中获得一席之地。(C)2001年欧洲心脏病学会。
Inflammation can be defined as the reaction of a living vascularized tissue to a localized damage, and plays a role in both normal repair reactions and in the pathogenesis, of disease. Inflammatory phenomena are at the basis of a number of disease processes in virtually any systemic or organ-specific disease, ranging from classical rheumatic diseases to bronchial airway hyper-responsiveness, inflammatory bowel disease, kidney diseases, psoriasis and atopic eczema. Modulation of long-chain polyunsaturated fatty acid intake, mostly by increasing the relative proportions of n-3 versus n-6 fatty acids, is the clearest example of how diet may modulate the inflammatory process. It is possible that many of the environmentally attributable epidemiological differences in the incidence of inflammatory diseases among different populations can be tracked back to different nutritional intake of selected, quantitatively minor nutritional components such as omega-3 fatty acids. The increase in dietary intake of these compounds, or their pharmacological supplementation, leads to a moderate quenching of the inflammatory reaction which may prove useful in selected clinical conditions. The clarification of the mechanisms of the biological action of these, as well as of other dietary components, and a better documentation of the spectrum of clinical possibilities offered by dietary manipulation in the intake of such compound's, linking together classical nutritional science, molecular biology, epidemiology and clinical medicine, are a frontier for nutritional research in the years to come. This nutritional approach promises to gain a place in the therapy of some inflammatory disorders. (C) 2001 The European Society of Cardiology.