Inflammation-induced sensitization of the brain in term infants
Inflammation-induced sensitization of the brain in term infants
复制标题
DOI：
10.1111/dmcn.12723
复制
发表时间：
2015-04-01
影响因子：
3.8
通讯作者：
Gressens, Pierre
中科院分区：
文献类型：
--
作者：
Fleiss, Bobbi;Tann, Cally J.;Gressens, Pierre
围产期损伤是婴儿死亡的主要原因，幸存者通常与神经认知障碍、脑瘫（CP）和癫痫有关。导致围产期脑损伤的事件是多因素的。这篇综述描述了影响大脑的一个亚损伤因素如何使其对第二个损伤因素敏感，从而引起加剧的损伤级联反应。我们将回顾临床和实验证据，包括观察到患有新生儿脑病和脑瘫的足月婴儿的母婴感染率很高。此外，我们将讨论炎症对损伤（如缺氧缺血）致敏作用的临床前证据，我们目前对致敏过程基础机制的理解，以及神经保护的可能性。
Perinatal insults are a leading cause of infant mortality and amongst survivors are frequently associated with neurocognitive impairment, cerebral palsy (CP), and seizure disorders. The events leading to perinatal brain injury are multifactorial. This review describes how one sub-injurious factor affecting the brain sensitizes it to a second injurious factor, causing an exacerbated injurious cascade. We will review the clinical and experimental evidence, including observations of high rates of maternal and fetal infections in term-born infants with neonatal encephalopathy and cerebral palsy. In addition, we will discuss preclinical evidence for the sensitizing effects of inflammation on injuries, such as hypoxia-ischaemia, our current understanding of the mechanisms underpinning the sensitization process, and the possibility for neuroprotection.