Plasma Selectins in Patients with Obstructive Sleep Apnea
Plasma Selectins in Patients with Obstructive Sleep Apnea
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DOI：
10.1007/978-94-007-4549-0_15
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发表时间：
2013-01-01
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影响因子：
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通讯作者：
Torlinski, L.
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文献类型：
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作者：
Cofta, S.;Wysocka, E.;Torlinski, L.
阻塞性睡眠呼吸暂停（obstructive sleep apnea，OSA）是心血管疾病发病的独立危险因素。该研究的目的是分析三种参与动脉粥样硬化斑块发展的特异性粘附分子：E-选择素（内皮）、L-选择素（白细胞表面）和P-选择素（来自血小板），这些分子在不同OSA严重程度的患者血浆中循环。80名年龄在30-64岁的非吸烟男性白人在临床、生化和多导睡眠图检查后入组研究。根据呼吸暂停低通气指数（AHI）的测定结果将患者分为4组：OSA-0组20例，AHI 0 ~ 4.9; OSA-1组21例，AHI 5-15; OSA-2组18例，AHI 16-30;检测全血细胞计数、口服葡萄糖耐量试验、空腹血脂、C-反应蛋白、胰岛素及血浆可溶性E-选择素、P-选择素和L-选择素水平。我们发现随着OSA的严重程度，所有三种选择素的浓度逐渐增加。总之，血浆粘附分子水平可能是OSA严重程度的指标，并可能导致心血管后遗症。
Obstructive sleep apnea (OSA) is an independent risk factor in the pathogenesis of cardiovascular diseases. The aim of the study was to analyze three specific adhesion molecules involved in the development of an atherosclerotic plaque: E-selectin (endothelium), L-selectin (leukocyte surface), and P-selectin (from platelet), circulating in plasma in patients at different OSA severity. Eighty non-smoking male Caucasians aged 30-64 were enrolled into the study after clinical, biochemical, and polysomnographic examinations. The patients were divided into four groups based on the results of apnea/hypopnea index (AHI): OSA-0 with AHI 0-4.9 (n = 20), OSA-1 with AHI 5-15 (n = 21), OSA-2 with AHI 16-30 (n = 18), OSA-3 with AHI >= 31 (n = 21). Complete blood count, oral glucose tolerance test, fasting lipid pro file, C-reactive protein and insulin, and plasma concentrations of soluble E-selectin, P-selectin and L-selectin were measured. We found a progressive increase in the concentrations of all three selectins with the severity of OSA. In conclusion, the level of plasma adhesion molecules may be indicative of OSA severity and may contribute to cardiovascular sequelae.