Uric Acid Levels in Tissues and Plasma of Mice during Aging
Uric Acid Levels in Tissues and Plasma of Mice during Aging
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DOI：
10.1248/bpb.b12-00198
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发表时间：
2012-08-01
影响因子：
2
通讯作者：
Ishigami, Akihito
中科院分区：
文献类型：
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作者：
Iwama, Mizuki;Kondo, Yoshitaka;Ishigami, Akihito
在这里，我们定量了C57 BL/6雄性小鼠的11种组织和血浆中的尿酸（UA）水平，以跟踪其在3至30个月的衰老过程中的周转。肾上腺、心脏和脾脏中的尿酸水平随着年龄的增长而增加，直到30个月大。同样，肝脏，肾脏，胰腺和睾丸中的UA水平增加，直到小鼠24个月大。肺和骨骼肌中的尿酸水平也分别从3至6个月和6至12个月上升，然后保持在几乎相同的水平，直到30个月大。在皮肤中，UA从3到6个月下降，然后保持几乎恒定，直到30个月大。此外，小肠和血浆中的尿酸水平在衰老过程中相当稳定。因此，我们对小鼠11种组织类型的评估表明，在衰老过程中，大多数组织中的UA水平都会增加。
Here we quantified the uric acid (UA) levels in 11 tissues and plasma of C57BL/6 male mice to track its turnover during 3 to 30 months of aging. UA levels in the adrenal glands, heart, and spleen increased with aging until 30 months of age. Similarly, UA levels in the liver, kidneys, pancreas, and testes increased until the mice were 24 months old. UA levels also rose in the lungs and skeletal muscles from 3 to 6 months and 6 to 12 months, respectively, and then remained at almost the same levels until 30 months of age. In the skin, UA decreased from 3 to 6 months and then stayed nearly constant until 30 months of age. Moreover, the small intestines and plasma had quite stable UA levels during aging. Thus, our assessment of 11 tissue types from mice showed that the UA levels increased in most tissues during aging.