Neurotoxic effects in adult mice neonatally exposed to 3,3′4,4′5-pentachlorobiphenyl or 2,3,3′4,4′-pentachlorobiphenyl.: Changes in brain nicotinic receptors and behaviour
Neurotoxic effects in adult mice neonatally exposed to 3,3′4,4′5-pentachlorobiphenyl or 2,3,3′4,4′-pentachlorobiphenyl.: Changes in brain nicotinic receptors and behaviour
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DOI：
10.1016/s1382-6689(97)10002-3
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发表时间：
1998-01-01
影响因子：
4.3
通讯作者：
Fredriksson, A
中科院分区：
文献类型：
--
作者：
Eriksson, P;Fredriksson, A
本研究的目的是调查新生儿暴露于单一的PCB同系物3，3 '，4，4'，5-五氯联苯是否（IUPAC 126）（共平面）和2，3，3 '，4，4 '-五氯联苯（国际化联105）（单次给药时单-邻位“共面样”）（0.14-14 μ mol/kg体重/口服）对10日龄雄性NMRI小鼠的毒性作用可在成年动物中诱导神经毒性作用，正如先前在某些邻位取代的多氯联苯中所观察到的那样。此外，为了确定行为失常，无论是在自发行为和学习和记忆功能，其次是胆碱能和/或多巴胺能系统的变化，以及行为变化是否会随着年龄的增长而恶化。研究发现，新生儿接触3，3 '，4，4'，5-五氯联苯可导致自发行为持续失常，而且这种失常会随着年龄增长而加重。此外，这种暴露还影响成年动物的学习和记忆功能，并且在表现出这种缺陷的动物中，海马中的胆碱能尼古丁受体也受到影响。接触相同或更高剂量的2，3，3 '，4，4'-五氯联苯不会导致所调查的行为变量、自发行为和游泳迷宫行为发生任何重大变化。(C)1998年Elsevier Science B.V.
The objective of the present study was to investigate whether neonatal exposure to single PCB congeners 3,3',4,4',5-pentachlorobiphenyl (IUPAC 126) (co-pIanar) and 2,3,3',4,4'-pentachlorobiphenyl (IUPAC 105) (mono-ortho 'co-planar like') when given as one single dose (0.14-14 mu mol/kg body weight per os) to 10 day old male NMRI mice could induce neurotoxic effects in the adult animal, as earlier seen for some ortho-substituted PCBs. Furthermore, to ascertain whether behavioural aberrations, both in spontaneous behaviour and in learning and memory function, were followed by changes in the cholinergic and/or the dopaminergic system, and whether behavioural changes could worsen with age. It was found that neonatal exposure to 3,3',4,4',5-pentachlorobiphenyl can induce persistent aberrations in spontaneous behaviour and that this derangement can grow worse with age. Furthermore, this exposure affected also learning and memory functions in the adult animal and in the animals showing this deficit, the cholinergic nicotinic receptors in the hippocampus were affected. Exposure to 2,3,3',4,4'-pentachlorobiphenyl, at the same dose or higher, did not cause any significant change in the investigated behavioural variables, spontaneous and swim-maze behaviour. (C) 1998 Elsevier Science B.V.