Current evidence on the relationship between five polymorphisms in the matrix metalloproteinases (MMP) gene and lung cancer risk: A meta-analysis
Current evidence on the relationship between five polymorphisms in the matrix metalloproteinases (MMP) gene and lung cancer risk: A meta-analysis
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DOI：
10.1016/j.gene.2012.12.085
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发表时间：
2013-03-15
期刊：
影响因子：
3.5
通讯作者：
Zhao, Jianping
中科院分区：
文献类型：
--
作者：
Hu, Chaoliang;Wang, Jianmiao;Zhao, Jianping
目的：基质金属蛋白酶（Matrix metalloproteinase， MMP） 1、MMP2、MMP3和MMP9是MMP家族的重要成员。近年来，关于MMP1-1607 1G/2G、MMP2-735 C/T、MMP2-1306 C/T、MMP3-1171 5A/6A和MMP9-1562 C/T多态性与肺癌风险的相关性研究较多。然而，由于不同病例对照研究的结果相互矛盾，这些研究的结果仍然不确定。为了澄清这些关联，我们进行了荟萃分析。方法：综合检索Medline、EMBASE、OVID和中国生物医学文献数据库（2000年1月- 2012年8月）。根据研究人群的种族进行总体和亚组分析。使用95%置信区间（95% ci）的优势比（OR）来评估这种关联的强度。结果：共有17项研究涉及4个MMP基因的5个多态性位点。对于MMP1-1607，显性模型下发现肺癌风险增加（MMP1-1607 1G/2G: OR = 1.14, 95%CI = 1.03-126, P = 0.01），但在高加索人群中没有。对于MMP2-1306 C/T， T多态性在显性和隐性模型下均降低肺癌风险（显性，OR = 0.63, 95%CI = 0.46 ~ 0.88, P = 0.0006；隐性，OR = 0.61, 95%CI = 0.38 ~ 0.99, P = 0.04）。对于MMP9-1562 C/T， TT基因型在隐性模型下降低了这种风险（OR = 0.38, 95%CI = 0.19-0.75, P = 0.005），但在亚洲人群中没有。对于MMP2-735 C/T和MMP3-1171 5A/6A，在显性和隐性模型下，这种多态性与肺癌风险没有关联。结论：MMP1-1607 1G/2G多态性增加亚洲人肺癌风险。mmp2 -1306 C/T多态性降低了亚洲人肺癌风险，而MMP9-1562 C/T多态性降低了白种人肺癌风险。MMP2-735 C/T与MMP3-1171 5A/6A基因型间差异无统计学意义。应该进行更大样本量的进一步研究。爱思唯尔B.V.版权所有
Purpose: Matrix metalloproteinase (MMP) 1, MMP2, MMP3 and MMP9 are important members of the MMP family. Recently, many studies have been carried out on the association between polymorphisms of MMP1-1607 1G/2G, MMP2-735 C/T, MMP2-1306 C/T, MMP3-1171 5A/6A and MMP9-1562 C/T and lung cancer risk. However the results of these studies remained inconclusive due to conflicting results from different case-control studies. To clarify these associations, we conducted a meta-analysis.Methods: We conducted a comprehensive search in Medline, EMBASE, OVID and Chinese Biomedical Literature Database (date from Jan 2000 to Aug 2012). Overall and subgroup analysis by the ethnicity of study population was carried out. Odds ratio (OR) with 95% confidence interval (95%CI) was used to assess the strength of the association.Results: There were 17 studies involving five polymorphic sites in four MMP genes. For MMP1-1607,increased lung cancer risk was found under dominant model (MMP1-1607 1G/2G: OR = 1.14, 95%CI = 1.03-126, P = 0.01), but not in the Caucasian population. For MMP2-1306 C/T, T polymorphism decreased lung cancer risk under dominant and recessive models (dominant, OR = 0.63, 95%CI = 0.46-0.88, P = 0.0006; recessive, OR = 0.61, 95%CI = 0.38-0.99, P = 0.04). For MMP9-1562 C/T, TT genotype decreased this risk under the recessive model (OR = 0.38, 95%CI = 0.19-0.75, P = 0.005), but not in the Asian population. For MMP2-735 C/T and MMP3-1171 5A/6A, there was no association between this polymorphism and lung cancer risk under the dominant and recessive models.Conclusions: MMP1-1607 1G/2G polymorphism increased lung cancer risk in Asians. It was also found thatMMP2-1306 C/T polymorphism decreased lung cancer risk in Asians, while MMP9-1562 C/T polymorphism decreased lung cancer risk in Caucasians. No significant difference was found in any genotype of MMP2-735 C/T and MMP3-1171 5A/6A. Further studies with larger sample sizes should be carried out. Crown Copyright (c) 2013 Published by Elsevier B.V. All rights reserved.