Morphological characteristics of lenticulostriate arteries in a large age-span population: Results from 7T TOF-MRA.
Morphological characteristics of lenticulostriate arteries in a large age-span population: Results from 7T TOF-MRA.
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DOI：
10.3389/fneur.2022.944863
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发表时间：
2022
影响因子：
3.4
通讯作者：
Zhang, Zihao
中科院分区：
文献类型：
--
作者：
Wei, Ning;Jing, Jing;Zhuo, Yan;Zhang, Zihao
豆纹动脉(LSA)起源于大脑中动脉(MCA)，供血至基底节。对其结构和功能的评价对皮质下梗塞的病因诊断至关重要。然而，LSA在健康人群中的特征仍然很少被描述。本研究旨在利用7T TOF-MRA对140名年龄范围较大(21-68岁)的健康志愿者进行LSA的形态测量。结果表明，随着年龄的增长，腰椎侧支的数量逐渐减少(r=−0.328，p<；0.001)，最大可见长度逐渐变短(r=−0.385，p<；0.001)。此外，基底节核的体积与LSA的形态也有显著的相关性。壳核体积与LSA的主干数(r=0.267，p<；0.001)和分支数(r=0.236，p<；0.001)密切相关，尾状核体积与LSA的最大可见长度密切相关(r=0.199，p=0.001)。综上所述，这项研究是第一次报道LSA形态的活体研究，样本量超过100例。这些发现对于了解LSA在衰老过程中的退变具有重要意义。
Lenticulostriate arteries (LSAs) originate from the middle cerebral artery (MCA) and supply blood to the basal ganglia. The evaluation of its structure and function is essential for the etiological diagnosis of subcortical infarction. However, the characteristics of LSA in a healthy population remain poorly described. Our study aims to acquire morphological measurements of LSA by 7T TOF-MRA on 140 healthy volunteers with a large age range (21–68 years). The results show that the number of branches of LSA gradually decreases with age (r = −0.328, p < 0.001), and the maximum visible length becomes shorter (r = −0.385, p < 0.001). Moreover, there is a significant correlation between the volume of the basal ganglia nuclei and the morphology of LSA. The volume of the putamen is associated with the number of stems (r = 0.267, p < 0.001) and branches (r = 0.236, p < 0.001) of LSAs, while the volume of caudate is closely related to the maximum visible length of LSAs (r = 0.199, p = 0.001). In conclusion, this study is the first in-vivo study to report the morphology of LSA with a large sample size of more than one hundred cases. These findings are valuable in understanding the degeneration of LSAs during aging.
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影响因子：
2.4
作者：
Marinkovic, S;Gibo, H;Cetkovic, M
通讯作者：
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影响因子：
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Harteveld AA;De Cocker LJ;Dieleman N;van der Kolk AG;Zwanenburg JJ;Robe PA;Luijten PR;Hendrikse J
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