Serial delayed cutaneous hypersensitivity skin testing with multiple recall antigens in healthy volunteers: booster effect study.
Serial delayed cutaneous hypersensitivity skin testing with multiple recall antigens in healthy volunteers: booster effect study.
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在健康志愿者中使用多种回忆抗原进行系列延迟性皮肤过敏皮肤测试：增强效应研究。
DOI：
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发表时间：
1985
期刊：
影响因子：
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通讯作者：
R. Moulias
中科院分区：
文献类型：
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作者：
Lesourd Bm;A. Wang;R. Moulias
Booster effects on delayed cutaneous hypersensitivity (DCH) responses have been demonstrated for various antigens when DCH is measured by the Mantoux technique. In the present study, we investigated this possibility when assessing DCH responses using the Multitest CMI multipuncture technique with simultaneous injections of seven test antigens and a control. The DCH responses were quantified for each antigen and for the overall DCH response expressed as a DCH score. In a group of healthy volunteers, DCH was repeatedly tested either 1 month apart or 2 months apart at least six times. When volunteers remained healthy, DCH variations were observed with only two of seven tested antigens: streptococcus which slowly decreased (P = .012) and proteus which slowly increased (P = .04). Responses to the other antigens and the DCH score remained stable. In contrast, greater DCH variations were observed when infections occurred. The results with the Multitest CMI multipuncture show that repeated application had minimal booster effect on DCH responses and may be used to evaluate and follow immunocompetence of patients.
