Survey of industrial workers for antibodies to toluene diisocyanate.
Survey of industrial workers for antibodies to toluene diisocyanate.
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对产业工人甲苯二异氰酸酯抗体的调查。
DOI：
10.1097/00043764-198111000-00007
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Karol,MH
中科院分区：
文献类型：
--
作者：
Karol,MH
在一家大型甲苯二异氰酸酯（TDI）生产公司的研究和开发设施进行了筛选程序。目的是确定选定的工人群体中TDI抗体的发生率。从103名员工谁暴露于6至24个月的TDI（0.02 ppm或更低）的工作场所环境浓度，在6个月的时间间隔获得血清。使用RAST（放射性过敏吸附试验）含有对甲苯基异氰酸酯-人血清白蛋白作为抗原，没有甲苯反应性IgE抗体检测血清中，当工人暴露于环境TDI浓度。在研究过程中，20名工人由于溢出或飞溅而急性暴露于TDI。4名急性暴露者中有3名出现抗体应答，这些患者伴有即刻呼吸道炎症和FEV降低20%或更高。相比之下，在9名工人中，只有一名工人在急性TDI暴露后立即出现呼吸道症状，但没有肺功能变化。其余急性暴露导致迟发性呼吸道疾病而无肺量变化或暴露时无症状的工人未出现血清学反应。在产生抗体的人中，在暴露后两个月内观察到甲苯反应性IgE增加。对工人进行甲苯反应性抗体的常规血清学筛查可能有助于确认可疑的异氰酸酯暴露，并提供TDI超敏反应的早期预警。
A screening program was undertaken at a research and development facility of a large toluene-diisocyanate (TDI) manufacturing corporation. The purpose was to determine the occurrence of antibodies to TDI in selected worker populations. Sera were obtained at 6-month intervals from 103 employees who were exposed from 6 to 24 months to ambient workplace concentrations of TDI (0.02 ppm or less). With the use of RAST (radioallergosorbent test) containing p-tolyl isocyanate-human serum albumin as antigen, no tolyl-reactive IgE antibodies were detected in sera when workers were exposed only to ambient TDI concentrations. During the study, 20 workers had acute exposures to TDI as a result of spills or splashes. Antibody responses developed in three of four individuals whose acute exposures were accompanied by immediate respiratory symptomatology and a decrease in FEV, of 20% or greater. By contrast, an antibody response developed in only one of nine workers with immediate respiratory symptoms but no spirometric changes upon acute TDI exposure. No serologic response developed in the remaining workers whose acute exposure resulted in delayed-onset respiratory symptomatology without spirometric changes, or who were asymptomatic at exposure. In persons developing antibodies, an increase in tolyl-reactive IgE was observed within two months of exposure. Routine serologic screening of workers for tolyl-reactive antibodies may be of value in confirming suspected isocyanate exposure and in providing an early warning of developing TDI hypersensitivity.