Effects of intensity of electroacupuncture upon experimental pain in healthy human volunteers: A randomized, double-blind, placebo-controlled study
Effects of intensity of electroacupuncture upon experimental pain in healthy human volunteers: A randomized, double-blind, placebo-controlled study
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DOI：
10.1016/j.pain.2006.01.012
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发表时间：
2006-05-01
期刊：
影响因子：
7.4
通讯作者：
Sim, Julius
中科院分区：
文献类型：
--
作者：
Barlas, Panos;Ting, Sharlene L. H.;Sim, Julius
电针通常用于缓解疼痛。尽管有广泛的证据基础指导刺激参数的选择，但关于提供有效剂量所需的强度水平，几乎没有方法学上可靠的研究。本研究调查了与安慰剂相比，两种刺激强度对无痛人的压痛阈值（PPT）的痛觉减退作用。48名未接受过穿刺术的志愿者（平均年龄23岁），按性别分层，筛选相关禁忌症，并随机分配到四组：对照组、安慰剂组、高强度组（“耐受但亚有害”）或低强度组（“强烈但舒适”）。使用Streitberger安慰剂针，对优势前臂（LI 10，TH 5）和同侧腿（GB 34，ST 38）上的穴位进行真电针或安慰剂电针。真针（长30 mm，直径0.3 mm）插入20-25 mm，激发活性组的“得气”，然后给予4 Hz，200 μ s的电针30 min。对照组和安慰剂组不进行电刺激，使用安慰剂针。干预期结束后，所有针头均被移除。志愿者们又被监视了30分钟。在基线和随后的6个10分钟间隔，由所有独立评定者从双侧第一背侧骨间肌腹采集两个PPT测量值。使用重复测量ANOVA分析平方根转换数据，基线数据作为协变量。高强度组的两个测量部位与安慰剂组有显著差异（p = 0.020，p = 0.033）。对照组随时间推移显示稳定的PPT读数。安慰剂组和对照组之间未观察到显著差异。这些发现表明，高强度水平可能是重要的最佳剂量选择。(c)2006年国际疼痛研究协会。Elsevier B. V.出版，保留所有权利。
Electroacupuncture is commonly used for pain relief. Despite an extensive evidence-base guiding the selection of stimulation parameters, little methodologically robust research exists regarding the level of intensity required to provide effective doses. This study investigated the hypoalgesic effects of two stimulation intensities compared to placebo on pressure pain thresholds (PPTs) in pain-free humans. Forty-eight acupuncture-naive volunteers (mean age 23), stratified by gender, were screened for relevant contraindications and randomly allocated to four groups: control, placebo, high-intensity ("to tolerance but sub-noxious") or low-intensity ("strong but comfortable"). True or placebo electroacupuncture, using the Streitberger placebo needle, was administered to acupoints on dominant forearm (LI10, TH5) and ipsilateral leg (GB34, ST38). True needles (30 mm long, 0.3 mm diameter) were inserted 20-25 mm and "de-qi" was elicited from active groups, prior to administering 30 min of 4 Hz, 200 mu s electroacupuncture. No electrical stimulation was performed on control and placebo groups, and placebo needles were used. After the intervention period, all needles were removed. Volunteers were monitored for 30 further minutes. Two PPT measurements were taken bilaterally from muscle bellies of first dorsal interosseous by ail independent rater, at baseline and at six subsequent 10-min intervals. Square-root transformed data were analysed using repeated-measures ANOVA, with baseline data as covariate. The high-intensity group was significantly different from the placebo group for both measurement sites (p = .020, p = .033). The control group displayed stable PPT readings over time. No significant differences were observed between the placebo and control groups. These findings suggest that high-intensity levels may be important in optimal dose selection. (c) 2006 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.